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AB276788

Recombinant Mouse FGFRL1 protein (His tag)

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Recombinant Mouse FGFRL1 protein (His tag) is a Mouse Fragment protein, in the 1 to 374 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Fgfr5, Fgfrl1, Fibroblast growth factor receptor-like 1, FGF receptor-like protein 1, Fibroblast growth factor receptor 5, FGFR-5

1 Images
SDS-PAGE - Recombinant Mouse FGFRL1 protein (His tag) (AB276788)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse FGFRL1 protein (His tag) (AB276788)

SDS-PAGE analysis of ab276788

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q91V87

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPMASSSSSTSLPWP","proteinLength":"Fragment","predictedMolecularWeight":"40.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":374,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q91V87","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGFRL1 also known as Fibroblast Growth Factor Receptor-Like 1 is a protein with a molecular mass of approximately 120 kDa. This protein structurally resembles other members of the fibroblast growth factor receptors but lacks the intracellular kinase domain that characterizes them. It is expressed mainly in tissues such as the heart kidney and developing skeletal system. FGFRL1 acts mechanically as a receptor binding fibroblast growth factors but differing from its relatives due to its inability to transduce signals through a conventional kinase signaling pathway.
Biological function summary

FGFRL1 plays roles in growth and development processes by modulating interactions between cells and the extracellular environment. It does not independently form a signaling complex but modulates the activity of other fibroblast growth factor receptors by acting in a regulatory capacity. FGFRL1 contributes to tissue development and differentiation by influencing cell proliferation migration and apoptosis. This regulation is essential in proper organogenesis especially involving cardiovascular structures and bones.

Pathways

FGFRL1 interacts significantly with fibroblast growth factor signaling and phosphoinositide 3-kinase (PI3K)/AKT pathways. These pathways govern processes such as cellular growth and survival. FGFRL1 modulates interactions in the fibroblast growth factor pathway with related receptors like FGFR1 to FGFR4 modulating their signal without intrinsic kinase activity. It impacts PI3K/AKT signaling indirectly by altering receptor availability and potentially affecting downstream pathway cascades.

FGFRL1 links to skeletal disorders such as craniosynostosis where premature fusion of skull bones occurs. Mutations or dysregulations in FGFRL1 disrupt normal tissue development causing abnormal bone growth. Additionally FGFRL1 has associations with cardiac malformations due to its role in heart development. Despite its distinctive activity FGFRL1's dysregulation often ties into networks involving FGFR1 to FGFR4 in these pathologies showcasing involvement in broader growth factor signaling disruptions.
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Specifications

Form

Lyophilized

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General info

Function

Has a negative effect on cell proliferation.

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Product protocols

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Target data

Has a negative effect on cell proliferation.
See full target information Fgfrl1
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