JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276925

Recombinant Mouse Frizzled 5 protein (Fc Chimera)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Mouse Frizzled 5 protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 167 aa range, expressed in CHO cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Frizzled-5, Fz-5, mFz5, Fzd5

1 Images
SDS-PAGE - Recombinant Mouse Frizzled 5 protein (Fc Chimera) (AB276925)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Frizzled 5 protein (Fc Chimera) (AB276925)

SDS-PAGE analysis of ab276925

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

CHO cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9EQD0

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB75234

Anti-Frizzled 5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Frizzled 5 antibody (AB75234)

  • 0
  • 0
Proteins & Peptides

AB214604

Recombinant human IL-10RA protein (Fc Chimera)

  • 0
  • 0
Proteins & Peptides

AB165455

Recombinant Human ZNF358 protein

SDS-PAGE - Recombinant Human ZNF358 protein (AB165455)

  • 0
  • 0
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein

SDS-PAGE - Recombinant Human UBR1 protein (AB165841)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKP","proteinLength":"Fragment","predictedMolecularWeight":"42.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":167,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"CHO cells","accessionNumber":"Q9EQD0","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Frizzled 5 also known as FZD5 is a receptor that functions mechanically as a part of the Wnt signaling pathway. The Frizzled 5 protein has a molecular weight of around 75 kDa and is expressed in various tissues including the brain the eyes and the cardiovascular system. As a transmembrane receptor Frizzled 5 binds to Wnt ligands and activates intracellular signaling cascades mediating important cellular processes.
Biological function summary

Frizzled 5 participates in cellular communication and is part of the Wnt-frizzled protein complex. This complex plays a role in embryonic development cell proliferation and cell differentiation. Through its interaction with Wnt ligands Frizzled 5 can influence cell fate determination and contribute to the maintenance of stem cells. These activities are essential for development and tissue homeostasis.

Pathways

Knowledge of Frizzled 5 places it within both the canonical and non-canonical Wnt signaling pathways. In the canonical pathway Frizzled 5 associates with LRP5/6 co-receptors to stabilize β-catenin leading to gene transcription changes. In the non-canonical pathway it involves the activation of Ca2+ signaling. Proteins related to Frizzled 5 in these pathways include Dishevelled (DVL) and the Glycogen synthase kinase (GSK-3).

Research has linked Frizzled 5 to conditions like retinopathy of prematurity and colorectal cancer. In retinopathy Frizzled 5's interaction with Norrin—a protein related to eye vascular development—can lead to abnormal vascularization. In colorectal cancer alterations in the Wnt-Frizzled signaling are implicated with β-catenin accumulating as a consequence. The modification in these signaling pathways hints at the potential for therapeutic interventions targeting Frizzled 5.
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Receptor for Wnt proteins (PubMed : 11092808, PubMed : 18230341). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed : 18230341). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (PubMed : 11092808). In neurons, activation by WNT7A promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed : 11092808). Plays a role in ocular development (By similarity).

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Post-translational modifications

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.

style
left-column

Product protocols

style
left-column

Target data

Receptor for Wnt proteins (PubMed : 11092808, PubMed : 18230341). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed : 18230341). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (PubMed : 11092808). In neurons, activation by WNT7A promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed : 11092808). Plays a role in ocular development (By similarity).
See full target information Frizzled-5
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com