Recombinant Mouse FUCA1 protein (Tagged) is a Mouse Full Length protein, in the 18 to 452 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
L A P R R F T P D W Q S L D S R P L P S W F D E A K F G V F V H W G V F S V P A W G S E W F W W H W Q G D R M P A Y Q R F M T E N Y P P G F S Y A D F A P Q F T A R F F H P D Q W A E L F Q A A G A K Y V V L T T K H H E G F T N W P S P V S W N W N S K D V G P H R D L V G E L G A A V R K R N I R Y G L Y H S L L E W F H P L Y L L D K K N G F K T Q H F V R A K T M P E L Y D L V N S Y K P D L I W S D G E W E C P D T Y W N S T S F L A W L Y N D S P V K D E V I V N D R W G Q N C S C H H G G Y Y N C Q D K Y K P Q S L P D H K W E M C T S M D R A S W G Y R K D M T M S T I A K E N E I I E E L V Q T V S L G G N Y L L N I G P T K D G L I V P I F Q E R L L A V G K W L Q I N G E A I Y A S K P W R V Q S E K N K T V V W Y T T K N A T V Y A T F L Y W P E N G I V N L K S P K T T S A T K I T M L G L E G D L S W T Q D P L E G V L I S L P Q L P P T V L P V E F A W T L K L T K V N
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Tissue alpha-L-fucosidase, Alpha-L-fucosidase I, Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase 1, Fuca1, Fuca
Recombinant Mouse FUCA1 protein (Tagged) is a Mouse Full Length protein, in the 18 to 452 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Mouse
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
L A P R R F T P D W Q S L D S R P L P S W F D E A K F G V F V H W G V F S V P A W G S E W F W W H W Q G D R M P A Y Q R F M T E N Y P P G F S Y A D F A P Q F T A R F F H P D Q W A E L F Q A A G A K Y V V L T T K H H E G F T N W P S P V S W N W N S K D V G P H R D L V G E L G A A V R K R N I R Y G L Y H S L L E W F H P L Y L L D K K N G F K T Q H F V R A K T M P E L Y D L V N S Y K P D L I W S D G E W E C P D T Y W N S T S F L A W L Y N D S P V K D E V I V N D R W G Q N C S C H H G G Y Y N C Q D K Y K P Q S L P D H K W E M C T S M D R A S W G Y R K D M T M S T I A K E N E I I E E L V Q T V S L G G N Y L L N I G P T K D G L I V P I F Q E R L L A V G K W L Q I N G E A I Y A S K P W R V Q S E K N K T V V W Y T T K N A T V Y A T F L Y W P E N G I V N L K S P K T T S A T K I T M L G L E G D L S W T Q D P L E G V L I S L P Q L P P T V L P V E F A W T L K L T K V N
Full Length
66.6 kDa
18 to 452
Recombinant
His tag N-Terminus
Liquid
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
Belongs to the glycosyl hydrolase 29 family.
Lysosome
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as 'alpha-L-fucosidase' or more commonly 'FUCA1' works as an enzyme breaking down complex carbohydrates by removing terminal alpha-L-fucose residues. This enzyme weighs approximately 51 kDa. It mainly expresses in tissues such as the liver pancreas and kidney playing a role in glycoprotein metabolism. Sometimes researchers refer to it simply as 'fucosidase' reflecting its central activity in fucose metabolism.
FUCA1 impacts various cellular functions through its role in glycan processing. This enzyme is not typically part of a larger complex working independently to hydrolyze glycosidic bonds. Its action is important in the catabolism of fucosylated glycoproteins and glycolipids influencing cell signaling and recognition. Alterations in FUCA1 activity can disrupt these processes affecting cellular homeostasis.
FUCA1 plays a role in the metabolism of glycosaminoglycans and glycoproteins. It contributes to the lysosomal degradation pathway alongside related enzymes such as beta-galactosidase. FUCA1's activity ensures the correct recycling of glycoproteins maintaining the balance of cellular components. The defect or overactivity of FUCA1 may have cascading effects throughout these pathways linking it with potential metabolic imbalances.
FUCA1 connects closely with fucosidosis a lysosomal storage disorder caused by FUCA1 deficiency. This leads to an accumulation of fucose-containing compounds resulting in progressive neurological decline. Additionally some studies suggest a link between altered FUCA1 expression and certain cancers due to its role in cellular recognition and signaling. In cancer this enzyme's interaction with other glycoprotein-processing enzymes becomes highlighted highlighting the complex interplay within disease contexts.
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