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AB187224

Recombinant mouse GDNF protein (Animal Free)

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Recombinant mouse GDNF protein (Animal Free) is a Mouse Full Length protein, in the 78 to 211 aa range, expressed in Escherichia coli, with >98%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Glial cell line-derived neurotrophic factor, mGDNF, Astrocyte-derived trophic factor, ATF, Gdnf

Key facts

Purity

>98% SDS-PAGE

Endotoxin level

<1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

The activity is determined by the dose-dependent proliferation of C6 cells and is typically less than 1 μg/mL.

Accession

P48540

Animal free

Yes

Carrier free

No

Species

Mouse

Reconstitution

Reconstitute at 0.1 mg/mL in water

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSPDKQAALPRRENRNRQAAAASPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCESAETMYDKILKNLSRSRRLTSDKVGQACCRPVAFDDDLSFLDDNLVYHILRKHSAKRCGCI","proteinLength":"Full Length","predictedMolecularWeight":"30.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":211,"aminoAcidStart":78,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48540","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA)
True
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Specifications

Form

Lyophilized

Additional notes

Determined by reducing and Non-reducing SDS-PAGE

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General info

Function

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest.

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

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Product protocols

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Target data

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest.
See full target information Gdnf
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