JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB226282

Recombinant Mouse Glutaminyl cyclase protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Mouse Glutaminyl cyclase protein (His tag) is a Mouse Full Length protein, in the 36 to 362 aa range, expressed in Mammalian, with >90%, suitable for SDS-PAGE.

View Alternative Names

Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, Glutaminyl-tRNA cyclotransferase, QC, Qpct

1 Images
SDS-PAGE - Recombinant Mouse Glutaminyl cyclase protein (His tag) (AB226282)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Glutaminyl cyclase protein (His tag) (AB226282)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab226282 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Mammalian

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9CYK2

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

Product details

Previously labelled as QPCT.
style
left-column

Sequence info

[{"sequence":"AWTQEKNHHQPAHLNSSSLQQVAEGTSISEMWQNDLRPLLIERYPGSPGSYSARQHIMQRIQRLQAEWVVEVDTFLSRTPYGYRSFSNIISTLNPEAKRHLVLACHYDSKYFPRWDSRVFVGATDSAVPCAMMLELARALDKKLHSLKDVSGSKPDLSLRLIFFDGEEAFHHWSPQDSLYGSRHLAQKMASSPHPPGSRGTNQLDGMDLLVLLDLIGAANPTFPNFFPKTTRWFNRLQAIEKELYELGLLKDHSLERKYFQNFGYGNIIQDDHIPFLRKGVPVLHLIASPFPEVWHTMDDNEENLHASTIDNLNKIIQVFVLEYLHL","proteinLength":"Full Length","predictedMolecularWeight":"41.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":362,"aminoAcidStart":36,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"Q9CYK2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutaminyl cyclase also known by the alternate name 'QC' catalyzes the conversion of glutaminyl residues towards pyroglutamyl formation in proteins. This enzyme weighs around 39 kDa and is distributed across various tissues with significant expression in the brain and secretory tissues. The active site of this enzyme facilitates the cyclization of N-terminal glutaminyl and glutamyl residues influencing protein stability and function.
Biological function summary

This enzyme modifies peptide hormones and neuropeptides by enhancing their activity or stability. Glutaminyl cyclase does not usually operate within large protein complexes. However its activity is critical for processing secretory proteins into their mature forms. Modifications by the enzyme often regulate peptide function making it an important player in cellular communication processes.

Pathways

Glutaminyl cyclase plays an important role in the neuroendocrine cascade and protein maturation pathways. This enzyme's activity connects with other proteins like hormone receptors affecting their downstream signaling processes. It also shares connections with proteins involved in the proteolytic processing pathway ensuring maturation and activation of peptide substrates.

Malfunction of glutaminyl cyclase associates with Alzheimer's disease and amyloidosis. The enzyme's activity influences accumulation of pyroglutamyl-modified proteins which have links to amyloid plaque formation in Alzheimer's disease. This connection involves amyloid-beta peptides where glutaminyl cyclase enhances the aggregation potential through N-terminal cyclization. Effective modulation of this enzyme’s activity might represent a therapeutic approach for related disorders.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity).

Sequence similarities

Belongs to the glutaminyl-peptide cyclotransferase family.

style
left-column

Product protocols

style
left-column

Target data

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity).
See full target information Glutaminyl-peptide cyclotransferase
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB201172

Anti-Glutaminyl cyclase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutaminyl cyclase antibody (AB201172)

  • 0
  • 0
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein

SDS-PAGE - Recombinant Human ZP2 protein (AB159886)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691

SDS-PAGE - Recombinant Human Zinc finger protein 691 (AB162402)

  • 0
  • 0
Proteins & Peptides

AB159814

Recombinant Human Wnt9a protein

SDS-PAGE - Recombinant Human Wnt9a protein (AB159814)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com