Recombinant Mouse Glutaminyl cyclase protein (His tag) is a Mouse Full Length protein, in the 36 to 362 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
A W T Q E K N H H Q P A H L N S S S L Q Q V A E G T S I S E M W Q N D L R P L L I E R Y P G S P G S Y S A R Q H I M Q R I Q R L Q A E W V V E V D T F L S R T P Y G Y R S F S N I I S T L N P E A K R H L V L A C H Y D S K Y F P R W D S R V F V G A T D S A V P C A M M L E L A R A L D K K L H S L K D V S G S K P D L S L R L I F F D G E E A F H H W S P Q D S L Y G S R H L A Q K M A S S P H P P G S R G T N Q L D G M D L L V L L D L I G A A N P T F P N F F P K T T R W F N R L Q A I E K E L Y E L G L L K D H S L E R K Y F Q N F G Y G N I I Q D D H I P F L R K G V P V L H L I A S P F P E V W H T M D D N E E N L H A S T I D N L N K I I Q V F V L E Y L H L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity).
Alternative names
Glutaminyl-peptide cyclotransferase, Glutaminyl cyclase, Glutaminyl-tRNA cyclotransferase, QC, Qpct
Recommended products
Recombinant Mouse Glutaminyl cyclase protein (His tag) is a Mouse Full Length protein, in the 36 to 362 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9CYK2-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- A W T Q E K N H H Q P A H L N S S S L Q Q V A E G T S I S E M W Q N D L R P L L I E R Y P G S P G S Y S A R Q H I M Q R I Q R L Q A E W V V E V D T F L S R T P Y G Y R S F S N I I S T L N P E A K R H L V L A C H Y D S K Y F P R W D S R V F V G A T D S A V P C A M M L E L A R A L D K K L H S L K D V S G S K P D L S L R L I F F D G E E A F H H W S P Q D S L Y G S R H L A Q K M A S S P H P P G S R G T N Q L D G M D L L V L L D L I G A A N P T F P N F F P K T T R W F N R L Q A I E K E L Y E L G L L K D H S L E R K Y F Q N F G Y G N I I Q D D H I P F L R K G V P V L H L I A S P F P E V W H T M D D N E E N L H A S T I D N L N K I I Q V F V L E Y L H L
- Accession
- Q9CYK2
- Protein length
- Full Length
- Predicted molecular weight
- 41.6 kDa
- Amino acids
- 36 to 362
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity).
- Sequence similarities
Belongs to the glutaminyl-peptide cyclotransferase family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as QPCT.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Glutaminyl cyclase also known by the alternate name 'QC' catalyzes the conversion of glutaminyl residues towards pyroglutamyl formation in proteins. This enzyme weighs around 39 kDa and is distributed across various tissues with significant expression in the brain and secretory tissues. The active site of this enzyme facilitates the cyclization of N-terminal glutaminyl and glutamyl residues influencing protein stability and function.
- Biological function summary
This enzyme modifies peptide hormones and neuropeptides by enhancing their activity or stability. Glutaminyl cyclase does not usually operate within large protein complexes. However its activity is critical for processing secretory proteins into their mature forms. Modifications by the enzyme often regulate peptide function making it an important player in cellular communication processes.
- Pathways
Glutaminyl cyclase plays an important role in the neuroendocrine cascade and protein maturation pathways. This enzyme's activity connects with other proteins like hormone receptors affecting their downstream signaling processes. It also shares connections with proteins involved in the proteolytic processing pathway ensuring maturation and activation of peptide substrates.
- Associated diseases and disorders
Malfunction of glutaminyl cyclase associates with Alzheimer's disease and amyloidosis. The enzyme's activity influences accumulation of pyroglutamyl-modified proteins which have links to amyloid plaque formation in Alzheimer's disease. This connection involves amyloid-beta peptides where glutaminyl cyclase enhances the aggregation potential through N-terminal cyclization. Effective modulation of this enzyme’s activity might represent a therapeutic approach for related disorders.
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1 product image
SDS-PAGE - Recombinant Mouse Glutaminyl cyclase protein (His tag) (ab226282)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab226282 with 5% enrichment gel and 15% separation gel.
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