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AB271531

Recombinant Mouse Glycogenin 1 + GYS1 protein (Tagged)

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Recombinant Mouse Glycogenin 1 + GYS1 protein (Tagged) is a Mouse Full Length protein, in the 1 to 738 aa range, expressed in Baculovirus infected Sf9 cells, with >68%, suitable for SDS-PAGE.

View Alternative Names

Gyg, Gyg1, Glycogenin-1, GN-1, GN1

1 Images
SDS-PAGE - Recombinant Mouse Glycogenin 1 + GYS1 protein (Tagged) (AB271531)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Glycogenin 1 + GYS1 protein (Tagged) (AB271531)

SDS-PAGE analysis of 4 μg ab271531.

Key facts

Purity

>68% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9R062

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 8 Preservative: 1.7% Imidazole Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPLSRSLSVSSLPGLEDWEDEFDPENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYYLVGPYTEQGVRTQVELLEPPTPELKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQNEEKPYVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALAKAFPDHFTYEPHEVDATQGYRYPRPASVPPSPSLSRHSSPHQSEDEEEPRDGPLGEDSERYDEEEEAAKDRRNIRAPEWPRRASCSSSTGGSKRSNSVDTGPSSSLSTPTEPLSPTSSLGEERN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":738,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9Z1E4","tags":[]},{"sequence":"MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRMVVLTSPQVSDSMRKVLETVFDDVIMVDVLDSGDSAHLTLMKRPELGITLTKLHCWSLTQYSKCVFMDADTLVLSNIDDLFEREELSAAPDPGWPDCFNSGVFVYQPSIETYNQLLHLASEQGSFDGGDQGLLNTYFSGWATTDITKHLPFVYNLSSISIYSYLPAFKAFGKNAKVVHFLGRTKPWNYTYNPQTKSVNCDSQDPTVSHPEFLNLWWDTFTTNVLPLLQHHGLVKDASSYLMMEHVSGALSDLSFGEAPAAPQPSMSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9R062","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glycogen synthase 1 also known as GYS1 and Glycogenin 1 is an enzyme primarily responsible for conversion of glucose into glycogen. It acts by catalyzing the addition of glucose units from UDP-glucose to growing glycogen chains adding to the energy storage in cells. GYS1 has a molecular mass of approximately 85 kDa. Expression of this protein mainly occur in muscle and liver tissues where glycogen storage is important for energy management exhibiting an important role in these tissues.
Biological function summary

GYS1 functions as the primary enzyme responsible for glycogen synthesis within cells. This enzyme operates in a complex with glycogenin which serves as the primer necessary for glycogen biosynthesis initiation. The association ensures the formation of a glycogen molecule by elongating the glucose chain. Through this mechanism GYS1 enables the formation of substantial glycogen reserves essential for energy demand particularly in cells with high energy needs like muscle cells.

Pathways

The function of GYS1 integrates into the glycogenesis pathway allowing cells to effectively store glucose as glycogen. As part of this pathway GYS1 works alongside glycogen phosphorylase which breaks down glycogen during times of energy need. GYS1 activity is regulated by insulin signaling highlighting its connection to the the insulin signaling pathway which controls glucose metabolism. This regulation allows the cell to maintain energy homeostasis linking GYS1 to broader metabolic pathways.

Mutations and irregularities within the GYS1 gene can lead to conditions such as Glycogen Storage Disease type 0 and Type 2 Diabetes. Glycogen Storage Disease type 0 manifests due to a deficiency in glycogen synthase leading to fasting hypoglycemia and reduced glycogen in the liver. GYS1 also links to insulin signaling malfunctions making it relevant to the development of diabetes. This connection to disorders highlights its importance beside proteins like glycogen phosphorylase and insulin receptors in maintaining proper glucose and glycogen balance within the body.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.

Sequence similarities

Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.

Post-translational modifications

Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195.. Phosphorylated.

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Product protocols

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Target data

Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.
See full target information Gyg1

Additional targets

Gys1,Gys1
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