Recombinant Mouse GPRC5D VLP (Active) protein is a Mouse Full Length protein, in the 1 to 344 aa range, expressed in HEK 293, with >95% purity and < 1 EU/µg endotoxin level.
M Y E D C V K S T E D Y Y L F C D N E G P W A I V L E S L A V I G I V V T I L L L L A F L F L M R K V Q D C S Q W N V L P T Q F L F L L A V L G L F G L T F A F I I Q L N H Q T A P V R Y F L F G V L F A I C F S C L L A H A S N L V K L V R G R V S F C W T T I L F I A I G V S L L Q T I I A I E Y V T L I M T R G L M F E H M T P Y Q L N V D F V C L L I Y V L F L M A L T F F V S K A T F C G P C E N W K Q H G R L I F A T V L V S I I I W V V W I S M L L R G N P Q L Q R Q P H W D D A V I C I G L V T N A W V F L L I Y I I P E L S I L Y R S C R Q E C P T Q G N V C Q V P V Y Q R S F R M D T Q E P T R A R D S D G A Q E D V A L T A Y G T P I Q L Q S A D P S R E Y L I P S A T L S P Q Q D A G L
G-protein coupled receptor family C group 5 member D, Nrgn
Recombinant Mouse GPRC5D VLP (Active) protein is a Mouse Full Length protein, in the 1 to 344 aa range, expressed in HEK 293, with >95% purity and < 1 EU/µg endotoxin level.
Constituents: 99.99% PBS
Belongs to the G-protein coupled receptor 3 family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
The GPCR GPRC5D also known as the GPRC5D protein or by the code 6D9 in certain research contexts is a member of the G-protein-coupled receptors (GPCRs) superfamily. This family acts as a significant mediator of cellular responses to external signals. The GPRC5D has a mass of approximately 56 kDa. It is mainly expressed in the human bone marrow and the keratinocytes of the skin with notable absence in other tissues. It also appears in certain immune cells indicating its potential involvement in immune system responses.
The role of GPCR GPRC5D centers on cell signaling mechanisms within the immune system. GPCR GPRC5D engages in intracellular signaling cascades that modulate immune functions although it is not known to be part of a larger receptor complex. Its function may involve interactions with molecules that transmit environmental signals into cellular responses enhancing its importance in immune regulation and possibly other cellular functions.
GPCR GPRC5D participates in signaling pathways like the immune regulation pathway and the skin development pathway. It relates to proteins such as arrestins which link GPCRs to downstream signaling pathways. This connection hints at a regulatory role in cellular response where GPCR GPRC5D acts as a conduit for signal transduction balancing cellular responses to external stimuli and maintaining cellular homeostasis.
GPCR GPRC5D has associations with multiple myeloma and psoriasis. Its expression in bone marrow links it to multiple myeloma where its level might impact cancer progression. Proteins such as interleukin-17 and others relevant to psoriasis are connected to GPCR GPRC5D through skin-related pathways suggesting its role in inflammatory responses and potential as a therapeutic target for skin disorders. This illustrates GPRC5D's relevance in specific pathological conditions offering avenues for research into targeted treatments.
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