Recombinant Mouse Hemoglobin subunit zeta protein (His tag) is a Mouse Full Length protein, in the 1 to 142 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M S L M K N E R A I I M S M W E K M A A Q A E P I G T E T L E R L F C S Y P Q T K T Y F P H F D L H H G S Q Q L R A H G F K I M T A V G D A V K S I D N L S S A L T K L S E L H A Y I L R V D P V N F K L L S H C L L V T M A A R F P A D F T P E V H E A W D K F M S I L S S I L T E K Y R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
Alternative names
Hba-x, Hbz1, Hbz, Hemoglobin subunit zeta, Alpha-like embryonic globin chain x, Hemoglobin zeta chain, Zeta-globin
Recommended products
Recombinant Mouse Hemoglobin subunit zeta protein (His tag) is a Mouse Full Length protein, in the 1 to 142 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P06467-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 6
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.39% MES
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M S L M K N E R A I I M S M W E K M A A Q A E P I G T E T L E R L F C S Y P Q T K T Y F P H F D L H H G S Q Q L R A H G F K I M T A V G D A V K S I D N L S S A L T K L S E L H A Y I L R V D P V N F K L L S H C L L V T M A A R F P A D F T P E V H E A W D K F M S I L S S I L T E K Y R
- Accession
- P06467
- Protein length
- Full Length
- Predicted molecular weight
- 18.3 kDa
- Amino acids
- 1 to 142
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab229362 was purified using conventional chromatography techniques.
General info
- Function
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
- Sequence similarities
Belongs to the globin family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Hemoglobin subunit zeta also known as HBZ or ζ-globin is a protein subunit of hemoglobin present predominantly during early embryonic stages. It is a part of the alpha-globin gene cluster located on chromosome 16. This protein typically measures approximately 16 kDa in molecular weight. Expression of the zeta subunit is mostly confined to embryonic tissues including the yolk sac and early erythroid cells. Throughout development the presence of HBZ is significantly reduced as other globin genes take precedence for fetal and adult hemoglobin production.
- Biological function summary
Hemoglobin subunit zeta plays a role in the formation of embryonic hemoglobin specifically the ζ2ε2 or Gower-1 hemoglobin complex. This complex facilitates the transfer of oxygen from the mother to the developing embryo. The zeta subunit interacts with other globin genes to form early hemoglobin types critical for oxygen transport at this stage. It enables the initial establishment of a functional circulatory system during early development.
- Pathways
The Hemoglobin subunit zeta engages in the oxygen transport pathway important to the early stages of embryogenesis. As part of this pathway it directly interacts with epsilon-globin to form the embryonic Gower-1 hemoglobin. This pathway operates in parallel with but distinctly from the fetal hemoglobin pathway involving alpha and gamma globins. These interactions illustrate the complex switch and regulation of globin gene expression that occurs as development progresses.
- Associated diseases and disorders
Hemoglobin subunit zeta has associations with hemoglobinopathies such as alpha-thalassemia. Mutations or deletions in the alpha-globin gene cluster can impact HBZ production contributing to anemia and related disorders. Additionally its dysregulation can be a marker for developmental delays in hematopoiesis. Interactions with the alpha-globin proteins highlight the clinical relevance of studying HBZ mutations and their impacts on blood disorders.
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1 product image
SDS-PAGE - Recombinant Mouse Hemoglobin subunit zeta protein (His tag) (ab229362)
15% SDS-PAGE analysis of 3 μg ab229362.
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