Recombinant Mouse Hemopexin protein (His tag) is a Mouse Full Length protein, in the 1 to 460 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >98% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A R T A V A L N I L V L L G L C W S L A V A S P L P T A N G R V A E V E N G T K P D S D V P E H C L D T W S F D A A T M D H N G T M L F F K G E F V W R G H S G T R E L I S A R W K N P I T S V D A A F R G P D S V F L I K E D K V W V Y P P E K K E N G Y P K L F Q E E F P G I P Y P P D A A V E C H R G E C Q S E G V L F F Q G N R K W F W D F A T R T Q K E R S W S T V G N C T A A L R W L E R Y Y C F Q G N K F L R F N P V T G E V P P R Y P L D A R D Y F V S C P G R G H G R P R N G T A H G N S T H P M H S R C S P D P G L T A L L S D H R G A T Y A F T G S H Y W R L D S S R D G W H S W P I A H H W P Q G P S T V D A A F S W D D K V Y L I Q G T Q V Y V F L T K G G N N L V S G Y P K R L E K E L G S P P G I S L E T I D A A F S C P G S S R L Y V S S G R R L W W L D L K S G A Q A T W T E V S W P H E K V D G A L C L D K S L G P N T C S S N G S S L Y F I H G P N L Y C Y S S I D K L N A A K S L P Q P Q K V N S I L G C S Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
Alternative names
Hpxn, Hpx, Hemopexin
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Recombinant Mouse Hemopexin protein (His tag) is a Mouse Full Length protein, in the 1 to 460 aa range, expressed in HEK 293, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >98% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q91X72-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 6
Constituents: 0.87% Sodium chloride, 0.39% MES
Sequence info
Amino acid sequence
- M A R T A V A L N I L V L L G L C W S L A V A S P L P T A N G R V A E V E N G T K P D S D V P E H C L D T W S F D A A T M D H N G T M L F F K G E F V W R G H S G T R E L I S A R W K N P I T S V D A A F R G P D S V F L I K E D K V W V Y P P E K K E N G Y P K L F Q E E F P G I P Y P P D A A V E C H R G E C Q S E G V L F F Q G N R K W F W D F A T R T Q K E R S W S T V G N C T A A L R W L E R Y Y C F Q G N K F L R F N P V T G E V P P R Y P L D A R D Y F V S C P G R G H G R P R N G T A H G N S T H P M H S R C S P D P G L T A L L S D H R G A T Y A F T G S H Y W R L D S S R D G W H S W P I A H H W P Q G P S T V D A A F S W D D K V Y L I Q G T Q V Y V F L T K G G N N L V S G Y P K R L E K E L G S P P G I S L E T I D A A F S C P G S S R L Y V S S G R R L W W L D L K S G A Q A T W T E V S W P H E K V D G A L C L D K S L G P N T C S S N G S S L Y F I H G P N L Y C Y S S I D K L N A A K S L P Q P Q K V N S I L G C S Q
- Accession
- Q91X72
- Protein length
- Full Length
- Predicted molecular weight
- 50.4 kDa
- Amino acids
- 1 to 460
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
- Sequence similarities
Belongs to the hemopexin family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Hemopexin also known as HPX is a glycoprotein that transports heme in the blood. It has a molecular weight of approximately 57 kDa and is primarily expressed in the liver. Hemopexin binds to free heme with high affinity which prevents oxidative damage and conserves iron. It transports the heme to hepatocytes for breakdown and recycling protecting cells from iron-mediated toxicity and oxidative stress.
- Biological function summary
The hemopexin function relates to protecting tissues from the harmful effects of free heme. Hemopexin does not work as part of a complex in this process but mainly acts independently. Its high binding affinity plays an important role in maintaining heme homeostasis in the plasma and tissues. By controlling heme levels hemopexin supports overall cellular health and function.
- Pathways
The hemopexin molecular weight allows it to fit effectively within the heme metabolism and iron recycling pathways. This protein plays a significant role by delivering heme to the liver and facilitating its degradation by heme oxygenase. Hemopexin interacts closely with heme oxygenase and albumin two proteins important for the management of heme and iron levels in the body.
- Associated diseases and disorders
Several hemopexin functions contribute to the understanding of conditions such as hemolytic anemia and acute liver injury. In hemolytic anemia hemopexin helps mitigate the effects of increased heme levels due to excessive red blood cell breakdown. In the context of liver injury the protein assists in the detoxification process and supports hepatic function. Hemopexin-related proteins such as heme oxygenase link these diseases to hemopexin by their roles in managing oxidative stress and heme catabolism.
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SDS-PAGE - Recombinant Mouse Hemopexin protein (His tag) (ab276805)
SDS-PAGE analysis of ab276805
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