Recombinant mouse ICAM1 protein (Active)
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- What is this?
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Recombinant mouse ICAM1 protein (Active) is a Mouse Fragment protein, in the 28 to 221 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, Mass Spec, HPLC.
View Alternative Names
CD54, Icam-1, Icam1, Intercellular adhesion molecule 1, ICAM-1, MALA-2, MyD10
- FuncS
Supplier Data
Functional Studies - Recombinant mouse ICAM1 protein (Active) (AB277758)
Addition of PMA-induced HSB-2 cells to mouse ICAM1 coated plates (12.5 μg/mL, 100 μL/well) led to 40.75% specific cell adherence. Statistical analysis was performed using two-tailed unpaired t-test, **=p<0.01.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant mouse ICAM1 protein (Active) (AB277758)
Mass determination by ESI-TOF.
Predicted MW is 21191.80 Da (+/- 10 Da by ESI-TOF). Observed MW is 21195.45 Da. Additional masses at 21357.41 and 21519.53 are due to O-linked glycosylation.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant mouse ICAM1 protein (Active) (AB277758)
SDS-PAGE analysis of ab277758.
Cell based assay testing is performed on the first lot of protein only and is provided as a reference for protein activity; subsequent lots of protein must pass all biophysical quality control parameters that meet the same parameters as the first lot.
Lot : GR3373514-1
- HPLC
Supplier Data
HPLC - Recombinant mouse ICAM1 protein (Active) (AB277758)
HPLC analysis of ab277758.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Specifications
Form
Lyophilized
Additional notes
=95% Purity by HPLC
General info
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
Sequence similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Post-translational modifications
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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