Recombinant mouse ICOS Ligand/ICOSL protein (Active) is a Mouse Fragment protein, in the 48 to 279 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
T E V G A M V G S N V V L S C I D P H R R H F N L S G L Y V Y W Q I E N P E V S V T Y Y L P Y K S P G I N V D S S Y K N R G H L S L D S M K Q G N F S L Y L K N V T P Q D T Q E F T C R V F M N T A T E L V K I L E E V V R L R V A A N F S T P V I S T S D S S N P G Q E R T Y T C M S K N G Y P E P N L Y W I N T T D N S L I D T A L Q N N T V Y L N K L G L Y D V I S T L R L P W T S R G D V L C C V E N V A L H Q N I T S I S Q A E S F T G N N T K N P Q E T H N N E L K
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Ligand for the T-cell-specific cell surface receptor ICOS (PubMed:10549624, PubMed:10617205, PubMed:10657606). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells (PubMed:10549624, PubMed:10617205, PubMed:10657606). Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
CD275, B7h, B7h2, B7rp1, Icosl, Icoslg, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, LICOS, B7-H2, B7RP-1
Recombinant mouse ICOS Ligand/ICOSL protein (Active) is a Mouse Fragment protein, in the 48 to 279 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcγR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Constituents: 100% PBS
Ligand for the T-cell-specific cell surface receptor ICOS (PubMed:10549624, PubMed:10617205, PubMed:10657606). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells (PubMed:10549624, PubMed:10617205, PubMed:10657606). Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.
Belongs to the immunoglobulin superfamily. BTN/MOG family.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
This product was previously labelled as ICOS Ligand
The ICOS Ligand also known as ICOSL B7-H2 and HK53 is a critical component in immune system function. This protein with a molecular mass of approximately 65 kDa is expressed on professional antigen-presenting cells such as dendritic cells macrophages and B cells. It plays a significant mechanical role in the immune response by engaging with its counter receptor the ICOS protein present on the surface of activated T cells. This interaction supports the regulation of T cell activity influencing proliferation and cytokine production.
ICOSL contributes to the modulation of immune responses. By forming a complex with the active ICOS protein ICOSL is involved in the co-stimulation of T cells. This process is important for the development of T-cell-dependent immune responses and helps in promoting the survival and differentiation of T cells. Together the ICOS ligand and ICOS protein create a dynamic interaction that balances immune activation and tolerance which is essential for maintaining immune homeostasis.
The ICOS-ICOSL interaction plays an important role in the T-cell receptor (TCR) signaling pathway. This pathway is fundamental for the activation of T cells and subsequent immune response. ICOSL also connects to the PI3K/Akt pathway where it impacts cell survival and proliferation. ICOS and the PI3K/Akt pathway work together to influence various aspects of immune regulation and adaptive immunity.
ICOSL has a notable impact on autoimmune diseases and cancer. Its function in immune modulation when dysregulated can contribute to autoimmune conditions such as systemic lupus erythematosus. In this context the abnormal activation of the ICOS protein may exaggerate immune responses leading to pathology. In cancer high expression of ICOSL can support tumor progression by affecting the immune surveillance capability. These associations reveal ICOSL’s role in balancing immune activation and inhibition which is important in the context of disease.
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