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AB276896

Recombinant mouse IFNA14 protein (His tag)

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Recombinant mouse IFNA14 protein (His tag) is a Full Length protein, in the 24 to 189 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
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Functional Studies - Recombinant mouse IFNA14 protein (His tag) (AB276896)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse IFNA14 protein (His tag) (AB276896)

Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is typically 5-40 pg/mL.

SDS-PAGE - Recombinant mouse IFNA14 protein (His tag) (AB276896)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant mouse IFNA14 protein (His tag) (AB276896)

SDS-PAGE analysis of ab276896

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE, FuncS

applications

Biologically active

Yes

Biological activity

Measured in antiviral assay using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is typically 5-40 pg/mL.

Animal free

No

Carrier free

No

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA14 antibody (AB235515)

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SDS-PAGE - Recombinant Human Ephrin A3 protein (denatured) (His tag N-Terminus) (AB156351)

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Proteins & Peptides

AB114584

Recombinant Human DPD protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human DPD protein (GST tag N-Terminus) (AB114584)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"CDLPQTHNLRNKRALTLLVKMRRLSPLSCLKDRKDFGFPQEKVDAQQIKKAQAIPVLSELTQQILTLFTSKDSSAAWDATLLDSFCNDLNTQLNDLQGCLMQQVEIQAPPLTQEDSLLAVRKYFHRITVYLREKKHSPCAWEVVRAEIWRALSSSAKLLTSLKEEK","proteinLength":"Full Length","predictedMolecularWeight":"20.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":null,"tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFNA14 also known as Interferon Alpha-14 is a low molecular weight protein weighing approximately 19.3 kDa. It belongs to the type I interferon family and functions as a cytokine. IFNA14 is primarily expressed in leukocytes where it exerts its effects on various immune responses. This protein contributes to the antiviral boundaries of cells by binding to specific cell-surface receptors.
Biological function summary

IFNA14 plays an essential role in the immune system response to viral infections. It interacts with the type I interferon receptor complex to activate transcription of interferon-stimulated genes which help to mediate antiviral effects. IFNA14 signals through the JAK-STAT pathway ultimately leading to an increased expression of MHC class I antigens and enhanced immune recognition. Its activity aids in the coordination of the immune system's efforts to combat viral pathogens.

Pathways

IFNA14 is integral to the interferon signaling pathway and plays a part in the innate immune response pathway. These pathways involve a cascade of proteins including JAK1 and STAT2 which mediate its signal transduction. The activation of these pathways leads to transcriptional changes necessary for an effective antiviral state and modulation of the immune response.

IFNA14 has connections with viral infections like Hepatitis C and systemic lupus erythematosus (SLE). Its dysregulation or overexpression can lead to an inappropriate immune response contributing to the pathogenesis of these conditions. The relationship between IFNA14 and other interferon-induced proteins such as IRF7 highlights its significance in disease progression and points to potential therapeutic targets.
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General info

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Product protocols

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Target data

See full target information IFNA14
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Product promise

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