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AB276985

Recombinant Mouse IFNA5 protein (His tag)

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Recombinant Mouse IFNA5 protein (His tag) is a Mouse Full Length protein, in the 1 to 189 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Interferon alpha-5, IFN-alpha-5, Ifna5

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SDS-PAGE - Recombinant Mouse IFNA5 protein (His tag) (AB276985)
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Supplier Data

SDS-PAGE - Recombinant Mouse IFNA5 protein (His tag) (AB276985)

SDS-PAGE analysis of ab276985

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P07349

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MARLCAFLMVLAVLSYWPTCSLGCDLPQTHNLRNKRALTLLVKMRRLSPLSCLKDRKDFGFPQEKVGAQQIQEAQAIPVLSELTQQVLNIFTSKDSSAAWNATLLDSFCNEVHQQLNDLKACVMQQVGVQESPLTQEDSLLAVRKYFHRITVYLREKKHSPCAWEVVRAEVWRALSSSVNLLARLSKEE","proteinLength":"Full Length","predictedMolecularWeight":"20.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P07349","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Interferon alpha-5 (IFNA5) also known as leukocyte interferon is part of the larger family of type I interferons. This protein weighs about 20 kilodaltons. It expresses mainly in leukocytes or white blood cells where it plays a role in the body's immune response. IFNA5 involves itself in antiviral defenses helping to identify and fight viral pathogens.
Biological function summary

This interferon functions in immune modulation and antiviral defense mechanisms. IFNA5 does not operate alone; it is involved with other signaling molecules to exert its effects contributing to a multi-protein complex known as the interferon-stimulated gene factor 3 (ISGF3). This complex activates the transcription of interferon-stimulated genes which are key players in the body's defense against viruses and other pathogens.

Pathways

Interferon alpha-5 contributes significantly to the Jak-STAT signaling pathway pivotal for transmitting information from chemical signals outside the cell to the cell nucleus. In this pathway it frequently interacts with proteins like Jak1 and STAT1 both essential in propagating antiviral and cellular defense signals. IFNA5 also engages in the innate immune response cooperating with other proteins to maintain and enhance defense against infectious agents.

Interferon alpha-5 has associations with viral infections and autoimmune diseases. Its dysregulation can result in disorders such as systemic lupus erythematosus (SLE) and chronic hepatitis B. In these conditions altered levels of IFNA5 may influence the severity and progression of the disease through their interaction with other proteins such as IRF7 and IL-6 which can contribute to inflammatory responses or immune system abnormalities.
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Specifications

Form

Lyophilized

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General info

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.

Sequence similarities

Belongs to the alpha/beta interferon family.

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Product protocols

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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information Ifna5
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