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AB233634

Recombinant mouse IGF2 protein (Animal Free)

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Recombinant mouse IGF2 protein (Animal Free) is a Mouse Full Length protein, in the 25 to 91 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Igf-2, Igf2, Insulin-like growth factor 2, Insulin-like growth factor II, Multiplication-stimulating polypeptide, IGF-II

2 Images
SDS-PAGE - Recombinant mouse IGF2 protein (Animal Free) (AB233634)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant mouse IGF2 protein (Animal Free) (AB233634)

1 μg ab233634 analyzed on a 4-20% Tris-Glycine gel, stained with Coomassie Blue.

Lane 1 : Non-reducing conditions.

Lane 2 : Reducing conditions.

Functional Studies - Recombinant mouse IGF2 protein (Animal Free) (AB233634)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse IGF2 protein (Animal Free) (AB233634)

ab233634 induced proliferation of FDC-P1 cells.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

<1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

FDC-P1 cell proliferation. ED50 ≤ 50 ng/ml (≥ 2.0 x 104 units/mg).

Accession

P09535

Animal free

Yes

Carrier free

No

Species

Mouse

Reconstitution

Reconstitute at 0.1 mg/mL in water

Storage buffer

Constituents: 0.1% Trifluoroacetic acid

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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AB100696

Mouse IGF2 ELISA Kit

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Sequence info

[{"sequence":"AYGPGETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSE","proteinLength":"Full Length","predictedMolecularWeight":"7.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":91,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09535","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
True
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Specifications

Form

Lyophilized

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General info

Function

The insulin-like growth factors possess growth-promoting activity (PubMed : 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed : 12087403, PubMed : 2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed : 16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed : 32557799).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Sequence similarities

Belongs to the insulin family.

Post-translational modifications

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The insulin-like growth factors possess growth-promoting activity (PubMed : 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed : 12087403, PubMed : 2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed : 16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed : 32557799).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
See full target information Igf2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

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Alternative Product
Proteins & Peptides

AB233678

Recombinant mouse IGF2 protein (Active)

proteins-peptides

recombinant-mouse-igf2-protein-active-ab233678

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