Recombinant mouse IL-15 protein (Active)
- Bioactive
- What is this?
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant mouse IL-15 protein (Active) is a Mouse Full Length protein, in the 49 to 162 aa range, expressed in Escherichia coli, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, Mass Spec.
View Alternative Names
Interleukin-15, IL-15, Il15
- FuncS
Supplier Data
Functional Studies - Recombinant mouse IL-15 protein (Active) (AB264456)
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is less or equal to 20 ng/ml.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant mouse IL-15 protein (Active) (AB264456)
SDS-PAGE - Recombinant mouse IL-15 protein (Active) (3 μg ab264456).
Visualized using Coomassie blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
nan
General info
Function
Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed : 11466332, PubMed : 8757333). Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed : 8757333). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed : 10882748, PubMed : 19632221).
Sequence similarities
Belongs to the IL-15/IL-21 family.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com