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AB256040

Recombinant mouse IL-16 protein (Active)

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(1 Publication)

Recombinant mouse IL-16 protein (Active) is a Mouse Fragment protein, in the 1197 to 1322 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Pro-interleukin-16, Il16

1 Images
SDS-PAGE - Recombinant mouse IL-16 protein (Active) (AB256040)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant mouse IL-16 protein (Active) (AB256040)

SDS-PAGE analysis of ab256040 (1μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions. ab256040 is predicted to have a MW of 13.2 kDa

4-20% Tris-Glycine gel. Coomassie Blue staining.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Primary human T cell chemotaxis (first detectable at 5 ng/mL).

Accession

O54824

Animal free

No

Carrier free

Yes

Species

Mouse

Reconstitution

Reconstitute at 0.1 mg/mL in water

Storage buffer

Constituents: 0.16% Sodium phosphate

storage-buffer

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGDRTGEMVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS","proteinLength":"Fragment","predictedMolecularWeight":"13.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":1322,"aminoAcidStart":1197,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O54824","tags":[]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
True
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Specifications

Form

Lyophilized

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General info

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Post-translational modifications

Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
See full target information Il16
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Emerging microbes & infections 13:2322663 PubMed38380651

2024

hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth.

Applications

Unspecified application

Species

Unspecified reactive species

Haibo Su,Shufeng Weng,Liulin Luo,Qin Sun,Taiyue Lin,Huixia Ma,Yumo He,Jing Wu,Honghai Wang,Wenhong Zhang,Ying Xu
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Product promise

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