Recombinant mouse IL-16 protein (Active) is a Mouse Fragment protein, in the 1197 to 1322 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
Amino acid sequence
M H D L N S S T D S A A S A S A A S D I S V E S K E A T V C T V T L E K T S A G L G F S L E G G K G S L H G D K P L T I N R I F K G D R T G E M V Q P G D E I L Q L A G T A V Q G L T R F E A W N V I K A L P D G P V T I V I R R T S L Q C K Q T T A S A D S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Alternative names
Pro-interleukin-16, Il16
Recommended products
Recombinant mouse IL-16 protein (Active) is a Mouse Fragment protein, in the 1197 to 1322 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
- Biological activity
- Primary human T cell chemotaxis (first detectable at 5 ng/mL).
- Accession
- O54824-1
- Animal free
- No
- Carrier free
- Yes
- Species
- Mouse
- Reconstitution
- Reconstitute at 0.1 mg/mL in water
- Concentration
- Storage buffer
Constituents: 0.16% Sodium phosphate
Sequence info
Amino acid sequence
- M H D L N S S T D S A A S A S A A S D I S V E S K E A T V C T V T L E K T S A G L G F S L E G G K G S L H G D K P L T I N R I F K G D R T G E M V Q P G D E I L Q L A G T A V Q G L T R F E A W N V I K A L P D G P V T I V I R R T S L Q C K Q T T A S A D S
- Accession
- O54824
- Protein length
- Fragment
- Predicted molecular weight
- 13.2 kDa
- Amino acids
- 1197 to 1322
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
- Post-translational modifications
Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant mouse IL-16 protein (Active) (ab256040)
SDS-PAGE analysis of ab256040 (1μg) under reducing (Lane 1) and non-reducing (Lane 2) conditions. ab256040 is predicted to have a MW of 13.2 kDa
4-20% Tris-Glycine gel. Coomassie Blue staining.
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