Recombinant Mouse IL-16 protein (His tag) is a Mouse Fragment protein, in the 1205 to 1322 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
M G S S H H H H H H S S G L V P R G S H M S A A S A S A A S D I S V E S K E A T V C T V T L E K T S A G L G F S L E G G K G S L H G D K P L T I N R I F K G T E Q G E M V Q P G D E I L Q L A G T A V Q G L T R F E A W N V I K A L P D G P V T I V I R R T S L Q C K Q T T A S A D S
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Pro-interleukin-16, Il16
Recombinant Mouse IL-16 protein (His tag) is a Mouse Fragment protein, in the 1205 to 1322 aa range, expressed in Escherichia coli, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
pH: 8
Constituents: 0.87% Sodium chloride, 0.24% Tris
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.
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