Recombinant Mouse IL36 gamma/IL-1F9 protein (His Tag)
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Recombinant Mouse IL36 gamma/IL-1F9 protein (His Tag) is a Mouse Full Length protein, in the 13 to 164 aa range, expressed in Escherichia coli, with <95%, <0.005 EU/µg endotoxin level, suitable for Mass Spec, SDS-PAGE.
View Alternative Names
Il1f9, Il36g, Interleukin-36 gamma, Interleukin-1 family member 9, IL-1F9
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Mouse IL36 gamma/IL-1F9 protein (His Tag) (AB318254)
Mass determination by ESI-TOF. Predicted MW is 20360.00 Da (+/- 10 Da by ESI-TOF). Observed MW is 20225.72Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse IL36 gamma/IL-1F9 protein (His Tag) (AB318254)
SDS-PAGE analysis of ab318254 under reducing conditions for 2ug protein.
Complementary Products
Primary Antibodies
AB273095
Anti-IL36 gamma/IL-1F9 antibody [EPR23333-107] - BSA and Azide free
RabMAb|Recombinant
![Western blot - Anti-IL36 gamma/IL-1F9 antibody [EPR23333-107] - BSA and Azide free (AB273095)](https://content.abcam.com/products/images/il36-gamma-il-1f9-antibody-epr23333-107-bsa-and-azide-free-ab273095--western-blot-img12257.jpg)
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Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IL36 gamma plays a role in the immune and inflammatory responses. It operates as a cytokine that signals through the IL-1 receptor family leading to the activation of NF-kB and MAPK pathways. This member of the IL-1 family does not form a complex by itself but interacts with IL-36R to exert its functions. The protein influences processes such as cell proliferation differentiation and the regulation of immune responses to external pathogens or injuries.
Pathways
IL36 gamma is involved in inflammatory and immune signaling pathways. Within the immune response pathway it stimulates the production of other cytokines and pro-inflammatory molecules. IL36 gamma is associated with the IL-1 signaling pathway alongside other cytokines such as IL-1 and IL-18 which all contribute to immune modulation and inflammatory responses.
Specifications
Form
Lyophilized
General info
Function
Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes.
Sequence similarities
Belongs to the IL-1 family.
Post-translational modifications
N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold) (PubMed:21965679). Proteolytically cleaved by cathepsin CTSG (By similarity).
Target data
Product promise
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