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AB276939

Recombinant Mouse Kallikrein 11 protein (His tag)

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Recombinant Mouse Kallikrein 11 protein (His tag) is a Mouse Full Length protein, in the 1 to 276 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Prss20, Klk11, Kallikrein-11, Hippostasin, Serine protease 20

1 Images
SDS-PAGE - Recombinant Mouse Kallikrein 11 protein (His tag) (AB276939)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse Kallikrein 11 protein (His tag) (AB276939)

SDS-PAGE analysis of ab276939

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9QYN3

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Assay Kits

AB213801

Human Kallikrein 11 ELISA Kit

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Primary Antibodies

AB233278

Anti-Kallikrein 11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB233278)

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Proteins & Peptides

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SDS-PAGE - Recombinant Human KPNA4 protein (AB114626)

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Proteins & Peptides

AB123169

Recombinant Human ACOT7 protein

SDS-PAGE - Recombinant Human ACOT7 protein (AB123169)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRRLKSDWKLSTETREPGARPALLQARMILRLIALALVTGHVGGETRIIKGYECRPHSQPWQVALFQKTRLLCGATLIAPKWLLTAAHCRKPHYVILLGEHNLEKTDGCEQRRMATESFPHPDFNNSLPNKDHRNDIMLVKMSSPVFFTRAVQPLTLSPHCVAAGTSCLISGWGTTSSPQLRLPHSLRCANVSIIEHKECEKAYPGNITDTMLCASVRKEGKDSCQGDSGGPLVCNGSLQGIISWGQDPCAVTRKPGVYTKVCKYFNWIHEVMRNN","proteinLength":"Full Length","predictedMolecularWeight":"27.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":276,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9QYN3","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 11 also known as hK11 is a secreted serine protease enzyme encoded by the KLK11 gene. It has an average molecular mass of approximately 30 kDa. This enzyme is mainly produced in various tissues including prostate spleen and thyroid playing a role in proteolytic processing. Kallikrein 11 has a function in post-translational modifications contributing to the activation and regulation of other proteins through cleavage.
Biological function summary

Kallikrein 11 functions as a significant participant in seminal fluid production and sperm motility. It plays roles in maintenance and regulation of these physiological processes. Kallikrein 11 is part of the extensive kallikrein-related peptidase family; hence it shares functional characteristics with other serine proteases in this family. It contributes to the breaking down of extracellular matrix proteins implicating it in tissue remodeling.

Pathways

Kallikrein 11 integrates into the kallikrein-kinin system and affects components involved in this biochemical network. This system impacts blood pressure regulation and inflammation processes. Kallikrein 11 acts in conjunction with other kallikreins and kinins leading to potential modulation of inflammatory responses and vascular functions. Its actions are related to pathways involving proteins such as prostatic acid phosphatase and prostate-specific antigen (PSA).

Kallikrein 11 has been implicated in prostate cancer and Alzheimer's disease. Increased expression of kallikrein 11 correlates with prostate cancer progression and serves as a potential biomarker for this condition. Additionally research suggests an association between aberrant kallikrein activity and Alzheimer's pathology though this involves more intricate enzymatic pathways with proteins like amyloid precursor protein (APP). Understanding its role in these diseases may offer new therapeutic avenues.
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Specifications

Form

Lyophilized

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General info

Function

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity).

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

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Product protocols

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Target data

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin (By similarity).
See full target information Klk11
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Product promise

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