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AB276944

Recombinant Mouse LRRTM4 protein (His tag)

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Recombinant Mouse LRRTM4 protein (His tag) is a Mouse Fragment protein, in the 1 to 424 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Leucine-rich repeat transmembrane neuronal protein 4, Lrrtm4

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SDS-PAGE - Recombinant Mouse LRRTM4 protein (His tag) (AB276944)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse LRRTM4 protein (His tag) (AB276944)

SDS-PAGE analysis of ab276944

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q80XG9

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGFRLITQLKGMSVFLVLFPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFKCLPNLQKLNLDSNKLTNVSQETVNAWISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQKPPFIPKPTIFKPDAVPATLEAVSPSPGFQIPGTDHEYEHVSFHK","proteinLength":"Fragment","predictedMolecularWeight":"46.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":424,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q80XG9","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LRRTM4 also known as Leucine Rich Repeat Transmembrane Neuronal 4 is a protein that plays a critical role in synaptic organization. It is a transmembrane protein mainly found in the postsynaptic density of excitatory synapses. LRRTM4 has a molecular mass of approximately 65 kDa. It is highly expressed in the brain particularly in regions involved in cognitive functions such as the hippocampus and cortex.
Biological function summary

The protein facilitates synapse development and maintenance influencing synaptic transmission by interacting with presynaptic partners. LRRTM4 acts as a synaptic organizer and is part of the postsynaptic membrane complex. It works closely with other synaptic proteins to facilitate synaptogenesis and maintain synaptic plasticity essential for learning and memory processes.

Pathways

LRRTM4 operates within neural communication pathways critical for synaptic development. It interacts with neurexins which are essential to the presynaptic organization forming complexes that aid neurotransmitter release. Furthermore it is involved in the organization of excitatory synapse pathways similar to its relative protein LRRTM2 which also shares a role in excitatory synaptic function.

The dysregulation of LRRTM4 expression has been linked to neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. Aberrant expression or function of LRRTM4 can contribute to the synaptic deficits observed in these conditions. The protein is associated with synaptic proteins like neuroligins which are implicated in similar neurodevelopmental disorders further emphasizing its importance in maintaining synaptic health.
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Specifications

Form

Lyophilized

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General info

Function

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).

Sequence similarities

Belongs to the LRRTM family.

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Product protocols

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Target data

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).
See full target information Lrrtm4
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Complementary Products

Primary Antibodies

AB234876

Anti-LRRTM4 antibody

Western blot - Anti-LRRTM4 antibody (AB234876)

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