Recombinant Mouse METRNL protein (His tag) is a Mouse Full Length protein, in the 46 to 311 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
Q Y S S D L C S W K G S G L T R E A R S K E V E Q V Y L R C S A G S V E W M Y P T G A L I V N L R P N T F S P A Q N L T V C I K P F R D S S G A N I Y L E K T G E L R L L V R D I R G E P G Q V Q C F S L E Q G G L F V E A T P Q Q D I S R R T T G F Q Y E L M S G Q R G L D L H V L S A P C R P C S D T E V L L A I C T S D F V V R G F I E D V T H V P E Q Q V S V I Y L R V N R L H R Q K S R V F Q P A P E D S G H W L G H V T T L L Q C G V R P G H G E F L F T G H V H F G E A Q L G C A P R F S D F Q R M Y R K A E E M G I N P C E I N M E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
Alternative names
Meteorin-like protein, Subfatin, Metrnl
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Recombinant Mouse METRNL protein (His tag) is a Mouse Full Length protein, in the 46 to 311 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q8VE43-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- Q Y S S D L C S W K G S G L T R E A R S K E V E Q V Y L R C S A G S V E W M Y P T G A L I V N L R P N T F S P A Q N L T V C I K P F R D S S G A N I Y L E K T G E L R L L V R D I R G E P G Q V Q C F S L E Q G G L F V E A T P Q Q D I S R R T T G F Q Y E L M S G Q R G L D L H V L S A P C R P C S D T E V L L A I C T S D F V V R G F I E D V T H V P E Q Q V S V I Y L R V N R L H R Q K S R V F Q P A P E D S G H W L G H V T T L L Q C G V R P G H G E F L F T G H V H F G E A Q L G C A P R F S D F Q R M Y R K A E E M G I N P C E I N M E
- Accession
- Q8VE43
- Protein length
- Full Length
- Predicted molecular weight
- 33.9 kDa
- Amino acids
- 46 to 311
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
- Sequence similarities
Belongs to the meteorin family.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
METRNL also known as Meteorin-like protein weighs approximately 33 kDa and plays an essential role in adipose tissue and muscle function. Expression of METRNL occurs in skeletal muscle and adipose tissue showcasing its importance in these tissues. METRNL being a secreted protein facilitates communication between cells in these tissues which means it participates in various physiological processes related to these areas.
- Biological function summary
Meteorin-like protein influences energy expenditure and thermogenesis. It enhances the browning of white adipose tissue leading to increased metabolic activity. METRNL acts as an upstream regulator for several metabolic pathways and interacts with cells involved in immune response signifying a potential role in regulating inflammation. While METRNL itself does not form a large protein complex it interacts with a network of signaling molecules that mediate its effects on energy balance.
- Pathways
The action of Meteorin-like protein integrates into pathways influencing the immune system and metabolism. METRNL has a functional link to the signal transducer and activator of transcription 3 (STAT3) pathway where it modulates cellular processes related to metabolism and inflammation. Additionally METRNL impacts the AMP-activated protein kinase (AMPK) pathway critical for energy homeostasis through its ability to enhance the browning of adipose tissue. These pathways underline METRNL's role in metabolic regulation and immune responses.
- Associated diseases and disorders
METRNL's functional attributes link it to metabolic diseases like obesity and insulin resistance. Its role in promoting energy expenditure and reducing pro-inflammatory signals showcases its potential relevance in these conditions. Additionally METRNL may influence muscle-related disorders due to its impact on muscle function. Through these pathways METRNL interacts with proteins like interleukin-6 (IL-6) known for its involvement in metabolic syndrome and inflammatory responses providing new insights into therapeutic strategies for managing these disorders.
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1 product image
SDS-PAGE - Recombinant Mouse METRNL protein (His tag) (ab239537)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab239537.
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