Recombinant Mouse MIP-3 beta/CCL19 Protein is a Mouse Full Length protein, in the 26 to 108 aa range, expressed in HEK 293, with >=95% purity and suitable for HPLC, SDS-PAGE, MS.
Images
Key facts
- Purity
- >=95% HPLC
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- HPLC, SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
G A N D A E D C C L S V T Q R P I P G N I V K A F R Y L L N E D G C R V P A V V F T T L R G Y Q L C A P P D Q P W V D R I I R R L K K S S A K N K G N S T R R S P V S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Alternative names
Elc, Scya19, Ccl19, C-C motif chemokine 19, Epstein-Barr virus-induced molecule 1 ligand chemokine, Small-inducible cytokine A19, EBI1 ligand chemokine, ELC
Recommended products
Recombinant Mouse MIP-3 beta/CCL19 Protein is a Mouse Full Length protein, in the 26 to 108 aa range, expressed in HEK 293, with >=95% purity and suitable for HPLC, SDS-PAGE, MS.
Key facts
- Purity
- >=95% HPLC
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- HPLC, SDS-PAGE, MS
- Biologically active
- No
- Accession
- O70460-1
- Animal free
- Yes
- Species
- Mouse
- Reconstitution
- Reconstitute in PBS
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Sequence info
Amino acid sequence
- G A N D A E D C C L S V T Q R P I P G N I V K A F R Y L L N E D G C R V P A V V F T T L R G Y Q L C A P P D Q P W V D R I I R R L K K S S A K N K G N S T R R S P V S
- Accession
- O70460
- Protein length
- Full Length
- Predicted molecular weight
- 9.27 kDa
- Actual molecular weight
- 9.29 kDa
- Amino acids
- 26 to 108
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
- Additional notes
SDS-PAGE >= 95%
General info
- Function
Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
- Sequence similarities
Belongs to the intercrine beta (chemokine CC) family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
MIP-3 beta also known as CCL19 is a chemokine involved in immune responses. It weighs around 11 kDa and is encoded by the CCL19 gene. MIP-3 beta does its function by binding to its receptor CCR7 which is common in lymph nodes and other lymphoid tissues. It recruits and directs the migration of immune cells especially T cells and dendritic cells navigating them towards lymphoid tissues. This makes MIP-3 beta integral in initiating and modulating immune responses.
- Biological function summary
MIP-3 beta helps direct cell trafficking within the lymphoid organs. It is not part of a complex but its interaction with the CCR7 receptor is essential for its biological activity. This binding plays a role in the development of secondary lymphoid organs and immune surveillance. Furthermore MIP-3 beta supports the homing of immune cells to appropriate locations impacting both innate and adaptive immune responses.
- Pathways
MIP-3 beta is associated with the chemokine signaling pathway and the immune system pathway. Through these pathways it interacts with proteins like CCR7 and other chemokines that regulate leukocyte migration and activation. These pathways ensure local and systemic immune responses are efficiently orchestrated impacting inflammation and immune regulation.
- Associated diseases and disorders
MIP-3 beta has connections to autoimmune diseases like rheumatoid arthritis and cancer. Its deregulation can result in abnormal immune surveillance contributing to the pathology of these conditions. MIP-3 beta regulates immune cell infiltration and any imbalance may also link it to other inflammatory disorders. Relations to proteins such as CCR7 in these conditions emphasize its role in disease pathogenesis and highlight its potential as a therapeutic target.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
SDS-PAGE - Recombinant Mouse MIP-3 beta/CCL19 Protein (ab307797)
SDS-PAGE analysis of ab307797
HPLC - Recombinant Mouse MIP-3 beta/CCL19 Protein (ab307797)
SDS-PAGE analysis of ab307797
Mass Spectrometry - Recombinant Mouse MIP-3 beta/CCL19 Protein (ab307797)
Mass determination by ESI-TOF. Predicted MW is 9273.73 Da (+/- 10 Da by ESI-TOF). Observed MW is 9288.26 Da.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com