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Recombinant Mouse Neuropilin 1 protein (His tag) is a Mouse Fragment protein, in the 22 to 856 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

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Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

F R S D K C G G T I K I E N P G Y L T S P G Y P H S Y H P S E K C E W L I Q A P E P Y Q R I M I N F N P H F D L E D R D C K Y D Y V E V I D G E N E G G R L W G K F C G K I A P S P V V S S G P F L F I K F V S D Y E T H G A G F S I R Y E I F K R G P E C S Q N Y T A P T G V I K S P G F P E K Y P N S L E C T Y I I F A P K M S E I I L E F E S F D L E Q D S N P P G G M F C R Y D R L E I W D G F P E V G P H I G R Y C G Q K T P G R I R S S S G V L S M V F Y T D S A I A K E G F S A N Y S V L Q S S I S E D F K C M E A L G M E S G E I H S D Q I T A S S Q Y G T N W S V E R S R L N Y P E N G W T P G E D S Y K E W I Q V D L G L L R F V T A V G T Q G A I S K E T K K K Y Y V K T Y R V D I S S N G E D W I S L K E G N K A I I F Q G N T N P T D V V L G V F S K P L I T R F V R I K P V S W E T G I S M R F E V Y G C K I T D Y P C S G M L G M V S G L I S D S Q I T A S N Q A D R N W M P E N I R L V T S R T G W A L P P S P H P Y T N E W L Q V D L G D E K I V R G V I I Q G G K H R E N K V F M R K F K I A Y S N N G S D W K T I M D D S K R K A K S F E G N N N Y D T P E L R T F S P L S T R F I R I Y P E R A T H S G L G L R M E L L G C E V E A P T A G P T T P N G N P V D E C D D D Q A N C H S G T G D D F Q L T G G T T V L A T E K P T I I D S T I Q S E F P T Y G F N C E F G W G S H K T F C H W E H D S H A Q L R W S V L T S K T G P I Q D H T G D G N F I Y S Q A D E N Q K G K V A R L V S P V V Y S Q S S A H C M T F W Y H M S G S H V G T L R V K L R Y Q K P E E Y D Q L V W M V V G H Q G D H W K E G R V L L H K S L K L Y Q V I F E G E I G K G N L G G I A V D D I S I N N H I S Q E D C A K P T D L D K K N T E I K I D E T G S T P G Y E G E G E G D K N I S R K P G N V L K T L D P L E H H H H H H

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Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).

Alternative names

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Recombinant Mouse Neuropilin 1 protein (His tag) is a Mouse Fragment protein, in the 22 to 856 aa range, expressed in Baculovirus infected insect, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.

Alternative names

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Applications

SDS-PAGE

Accession
P97333-1
Animal free

No

Species

Mouse

Concentration
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Storage buffer

pH: 7.4
Constituents: 80% PBS, 20% Glycerol (glycerin, glycerine)

Sequence info

Amino acid sequence

F R S D K C G G T I K I E N P G Y L T S P G Y P H S Y H P S E K C E W L I Q A P E P Y Q R I M I N F N P H F D L E D R D C K Y D Y V E V I D G E N E G G R L W G K F C G K I A P S P V V S S G P F L F I K F V S D Y E T H G A G F S I R Y E I F K R G P E C S Q N Y T A P T G V I K S P G F P E K Y P N S L E C T Y I I F A P K M S E I I L E F E S F D L E Q D S N P P G G M F C R Y D R L E I W D G F P E V G P H I G R Y C G Q K T P G R I R S S S G V L S M V F Y T D S A I A K E G F S A N Y S V L Q S S I S E D F K C M E A L G M E S G E I H S D Q I T A S S Q Y G T N W S V E R S R L N Y P E N G W T P G E D S Y K E W I Q V D L G L L R F V T A V G T Q G A I S K E T K K K Y Y V K T Y R V D I S S N G E D W I S L K E G N K A I I F Q G N T N P T D V V L G V F S K P L I T R F V R I K P V S W E T G I S M R F E V Y G C K I T D Y P C S G M L G M V S G L I S D S Q I T A S N Q A D R N W M P E N I R L V T S R T G W A L P P S P H P Y T N E W L Q V D L G D E K I V R G V I I Q G G K H R E N K V F M R K F K I A Y S N N G S D W K T I M D D S K R K A K S F E G N N N Y D T P E L R T F S P L S T R F I R I Y P E R A T H S G L G L R M E L L G C E V E A P T A G P T T P N G N P V D E C D D D Q A N C H S G T G D D F Q L T G G T T V L A T E K P T I I D S T I Q S E F P T Y G F N C E F G W G S H K T F C H W E H D S H A Q L R W S V L T S K T G P I Q D H T G D G N F I Y S Q A D E N Q K G K V A R L V S P V V Y S Q S S A H C M T F W Y H M S G S H V G T L R V K L R Y Q K P E E Y D Q L V W M V V G H Q G D H W K E G R V L L H K S L K L Y Q V I F E G E I G K G N L G G I A V D D I S I N N H I S Q E D C A K P T D L D K K N T E I K I D E T G S T P G Y E G E G E G D K N I S R K P G N V L K T L D P L E H H H H H H

Accession

P97333

Protein length

Fragment

Predicted molecular weight

94.7 kDa

Amino acids

22 to 856

Nature

Recombinant

Tags

His tag C-Terminus

Specifications

Form

Liquid

Additional notes

Affinity purified

General info

Function

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).

Sequence similarities

Belongs to the neuropilin family.

Subcellular localisation

Mitochondrion membrane

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Product promise

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1 product image

  • SDS-PAGE - Recombinant Mouse Neuropilin 1 protein (His tag) (ab219287), expandable thumbnail

    SDS-PAGE - Recombinant Mouse Neuropilin 1 protein (His tag) (ab219287)

    15% SDS-PAGE analysis of 3 μg ab219287.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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