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Recombinant Mouse PAI1 + PLAT protein is a Mouse Full Length protein, expressed in Insect, with >95% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Mouse PAI1 + PLAT protein (AB92709), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Tags

Tag free

Applications

SDS-PAGE

Biologically active

No

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Targets

Plat

Alternative names

Recommended products

Recombinant Mouse PAI1 + PLAT protein is a Mouse Full Length protein, expressed in Insect, with >95% purity and suitable for SDS-PAGE.

Key facts

Purity

>95% SDS-PAGE

Expression system

Insect cells

Applications

SDS-PAGE

Accession
P22777-1
Animal free

No

Species

Mouse

Concentration
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Storage buffer

pH: 7.4
Constituents: 9.52% HEPES, 0.58% Sodium chloride

Sequence info

Amino acid sequence

Accession

P22777

Protein length

Full Length

Nature

Recombinant

Specifications

Form

Liquid

Additional notes

Mouse sc-tPA is reacted with an excess of Mouse PAI1 stable mutant at physiological pH. The resulting 1:1 molar complex is purified from the remaining PAI1 by affinity chromatography with immobilized antibodies to Mouse tPA.

General info

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Sequence similarities

Belongs to the serpin family.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Solubility: > 2 mg/mL

Spectrophotometric Data:
ε0.1%=1.5

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1 product image

  • SDS-PAGE - Recombinant Mouse PAI1 + PLAT protein (ab92709), expandable thumbnail

    SDS-PAGE - Recombinant Mouse PAI1 + PLAT protein (ab92709)

    10% SDS-PAGE

    Lane 1: Mouse PAI1, Non-reduced

    Lane 2: Mouse tPA, Non-reduced

    Lane 3: Mouse PAI1 + tPA, Non-reduced

    Lane 4: Mouse PAI1 + tPA, Reduced

    Lane 5: Mouse PAI1, Reduced

    Lane 6: Mouse tPA, Reduced

    Lane 7: Prestained standard

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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