Recombinant mouse PAI1 protein is a Mouse Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
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- PloS one 14:e02213662019Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShunshun Zhu et. al.PubMed 31442231
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
Amino acid sequence
L P L R E S H T A H Q A T D F G V K V F Q Q V V Q A S K D R N V V F S P Y G V S S V L A M L Q M T T A G K T R R Q I Q D A M G F K V N E K G T A H A L R Q L S K E L M G P W N K N E I S T A D A I F V Q R D L E L V Q G F M P H F F K L F Q T M V K Q V D F S E V E R A R F I I N D W V E R H T K G M I N D L L A K G A V D E L T R L V L V N A L Y F S G Q W K T P F L E A S T H Q R L F H K S D G S T V S V P M M A Q S N K F N Y T E F T T P D G L E Y D V V E L P Y Q G D T L S M F I A A P F E K D V H L S A L T N I L D A E L I R Q W K G N M T R L P R L L I L P K F S L E T E V D L R G P L E K L G M P D M F S A T L A D F T S L S D Q E Q L S V A Q A L Q K V R I E V N E S G T V A S S S T A F V I S A R M A P T E M V I D R S F L F V V R H N P T E T I L F M G Q V M E P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
Alternative names
Mr1, Pai1, Planh1, Serpine1, Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1
Recommended products
Recombinant mouse PAI1 protein is a Mouse Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
- Biological activity
- ab93068 is 80 (+/-) 5% active by uPA titration. The active fraction typically contains 70 percent active PAI1. Active concentration = ~2.0 mg/mL.
- Accession
- P22777
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 5
Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA
Sequence info
Amino acid sequence
- L P L R E S H T A H Q A T D F G V K V F Q Q V V Q A S K D R N V V F S P Y G V S S V L A M L Q M T T A G K T R R Q I Q D A M G F K V N E K G T A H A L R Q L S K E L M G P W N K N E I S T A D A I F V Q R D L E L V Q G F M P H F F K L F Q T M V K Q V D F S E V E R A R F I I N D W V E R H T K G M I N D L L A K G A V D E L T R L V L V N A L Y F S G Q W K T P F L E A S T H Q R L F H K S D G S T V S V P M M A Q S N K F N Y T E F T T P D G L E Y D V V E L P Y Q G D T L S M F I A A P F E K D V H L S A L T N I L D A E L I R Q W K G N M T R L P R L L I L P K F S L E T E V D L R G P L E K L G M P D M F S A T L A D F T S L S D Q E Q L S V A Q A L Q K V R I E V N E S G T V A S S S T A F V I S A R M A P T E M V I D R S F L F V V R H N P T E T I L F M G Q V M E P
- Accession
- P22777
- Protein length
- Full Length
- Amino acids
- 24 to 402
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).
- Sequence similarities
Belongs to the serpin family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Product promise
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1 product image
SDS-PAGE - Recombinant mouse PAI1 protein (ab93068)
10% SDS-PAGE
Lane 1: PAI1 (5 μg) Reduced
Lane 2: PAI1 (5 μg) +uPA-HTC (8 μg) Reduced
Lane 3: Prestained Standard
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