Recombinant mouse PDE11A protein (Active) (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDE11A also known as phosphodiesterase 11A is an enzyme that belongs to the phosphodiesterase family and exhibits a mass of approximately 101 kDa. It functions mechanically by hydrolyzing the second messengers cAMP and cGMP which play an important role in signal transduction. PDE11A expression occurs in various tissues with particularly high levels in the prostate testis and heart indicating its diverse physiological roles.

Biological function summary

PDE11A regulates intracellular concentrations of cyclic nucleotides affecting cellular responses to hormones and other signaling molecules. This enzyme is not part of a complex but interacts directly with second messengers involved in cellular signaling pathways. Through its hydrolyzing activity PDE11A modulates processes like cell proliferation and differentiation providing fine-tuning of cellular responses to environmental changes.

Pathways

PDE11A plays a role in the cAMP and cGMP signaling pathways which influence various biological processes including metabolism and vascular smooth muscle relaxation. It shares functionality with other phosphodiesterases such as PDE5 which also targets cGMP. PDE11A's regulation of these pathways indicates its importance in physiological equilibrium and response mechanisms.

PDE11A shows associations with conditions such as adrenal hyperplasia and prostate cancer. Altered PDE11A activity might affect hormone signaling contributing to the development of such disorders. Additionally PDE11A links to proteins like corticotropin-releasing hormone (CRH) which play a significant role in stress response and metabolic regulation further emphasizing its involvement in disease pathways.