Recombinant Mouse Prealbumin protein is a Mouse Fragment protein, in the 23 to 147 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
A G A G E S K C P L M V K V L D A V R G S P A V D V A V K V F K K T S E G S W E P F A S G K T A E S G E L H G L T T D E K F V E G V Y R V E L D T K S Y W K T L G I S P F H E F A D V V F T A N D S G H R H Y T I A A L L S P Y S Y S T T A V V S N P Q N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Alternative names
Transthyretin, Prealbumin, Ttr
Recommended products
Recombinant Mouse Prealbumin protein is a Mouse Fragment protein, in the 23 to 147 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P07309-1
- Animal free
No
- Species
Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
A G A G E S K C P L M V K V L D A V R G S P A V D V A V K V F K K T S E G S W E P F A S G K T A E S G E L H G L T T D E K F V E G V Y R V E L D T K S Y W K T L G I S P F H E F A D V V F T A N D S G H R H Y T I A A L L S P Y S Y S T T A V V S N P Q N
- Accession
- Protein length
Fragment
- Predicted molecular weight
13.5 kDa
- Amino acids
23 to 147
- Nature
Recombinant
Specifications
- Form
Liquid
General info
- Function
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
- Sequence similarities
Belongs to the transthyretin family.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Prealbumin also known as transthyretin is a protein with a molecular mass of approximately 55 kDa. The liver primarily synthesizes prealbumin and it is present in the bloodstream. Functionally prealbumin transports thyroxine and retinol-binding protein-retinol complex facilitating the distribution of these molecules to target tissues. As such it plays an integral role in maintaining retinol and thyroid hormone homeostasis.
- Biological function summary
Prealbumin interacts with retinol-binding protein to form a complex essential for vitamin A transportation. This complex prevents renal filtration of retinol-binding protein thereby conserving vitamin A in circulation. The protein's role extends beyond transport as it influences neurophysiological processes due to its ability to bind thyroid hormones and affect gene expression related to metabolism. Prealbumin is primarily a part of the thyroxine-transferring complex reinforcing its critical position in hormonal and vitamin dynamics.
- Pathways
Prealbumin's role in the thyroxine-binding globulin pathway highlights its importance in the endocrine system. Another pathway where prealbumin contributes significantly is the vitamin A metabolic pathway. In these pathways prealbumin maintains functional relationships with proteins like retinol-binding protein and thyroxine-binding globulin which jointly modulate thyroid hormone transport and vitamin A dynamics across cellular membranes.
- Associated diseases and disorders
Prealbumin directly associates with familial amyloid polyneuropathy and malnutrition. Familial amyloid polyneuropathy involves the deposition of prealbumin-derived amyloid fibrils in peripheral nerves impacting neuron function. In malnutrition decreased prealbumin levels serve as a biomarker reflecting poor nutritional status. Clinically prealbumin's relation to retinol-binding protein and thyroid hormone levels facilitates its use in diagnosing and monitoring these conditions.
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1 product image
SDS-PAGE - Recombinant Mouse Prealbumin protein (ab226451)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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