Recombinant Mouse Prokineticin 2/PK2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prokineticin 2 also known as PK2 is a peptide hormone weighing approximately 10 kDa. PK2 is largely expressed in the suprachiasmatic nucleus and various other brain regions including peripheral tissues such as the testes and intestines. Mechanically PK2 interacts with the prokineticin receptors PKR1 and PKR2 to produce its effects. It binds these G protein-coupled receptors (GPCRs) and activates intracellular signaling cascades influencing many physiological processes.

Biological function summary

PK2 plays significant roles in various regulatory functions in the body. It partakes in the circadian rhythm regulation reproductive functions and the modulation of pain perception. While PK2 functions independently it often interacts with other proteins in intricate signaling networks to achieve its biological effects. Its expression is responsive to environmental light and is intricately tied to the body’s clock system.

Pathways

PK2 is an essential component of the circadian rhythm and reproductive systems. In the circadian system PK2 acts within the light-entrainment pathway synchronizing biological rhythms. PK2 connects with proteins like BMAL1 and CLOCK forming links through feedback loops that are important for rhythm generation. In reproductive pathways PK2 influences gonadotropin-releasing hormone (GnRH) release contributing to fertility regulation.

PK2 involvement becomes notable in conditions like infertility and sleep disorders. PK2 dysregulation can contribute to abnormal circadian signals which may impact sleep patterns. Additionally the PK2-GnRH axis can affect reproductive health linking PK2 to fertility issues. The protein’s connection with other proteins like PKR1 during these pathological conditions underlines its potential as a target for therapeutic intervention.