Recombinant Mouse Prorenin protein is a Mouse Full Length protein, expressed in HEK 293 and with >95% purity.
>95% SDS-PAGE
HEK 293 cells
Tag free
No
Select an associated product type
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Ren-2, Renin-2, Angiotensinogenase, Submandibular gland renin
Recombinant Mouse Prorenin protein is a Mouse Full Length protein, expressed in HEK 293 and with >95% purity.
>95% SDS-PAGE
HEK 293 cells
Tag free
No
P00796
No
Mouse
pH: 8
Constituents: 0.605% Tris
Liquid
ab93313 is purified by chelated metal affinity chromatography.
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Belongs to the peptidase A1 family.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
Prorenin also known as angiotensinogenase is a precursor form of renin. This protein plays a vital role in the renin-angiotensin system (RAS) which regulates blood pressure and electrolyte balance. Prorenin is primarily synthesized in the juxtaglomerular cells of the kidney and possesses a molecular weight of approximately 40 kDa. It exists in an inactive form until it is cleaved to form active renin. It moves through the bloodstream to reach target tissues.
Prorenin initiates the conversion of angiotensinogen to angiotensin I an important step in the RAS. In its inactive form prorenin circulates throughout the body but remains ready for activation. The activation involves a non-proteolytic conformational change or proteolytic cleavage within the kidneys. Prorenin may exist as part of a complex with the (pro)renin receptor which influences various physiological processes beyond blood pressure regulation.
This precursor functions as an important regulator within the renin-angiotensin system. Prorenin by forming renin is directly involved with the conversion of angiotensinogen into angiotensin I. This initial step leads to further pathways that construct angiotensin II a potent vasoconstrictor affecting the vascular system. The activity of angiotensin II ties closely to the actions of the enzyme angiotensin-converting enzyme (ACE) which transforms angiotensin I to angiotensin II.
Prorenin's activation links strongly to conditions such as hypertension and diabetic nephropathy. Elevated prorenin levels have been observed in individuals with hypertension indicating its central role in this disorder. Furthermore its interaction with the (pro)renin receptor contributes to the progression of renal disease in diabetes-related nephropathy. The relationship among prorenin renin and the (pro)renin receptor provides significant implications for therapeutic strategies targeting these conditions.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com