Recombinant Mouse Reg3a protein (His tag)
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Recombinant Mouse Reg3a protein (His tag) is a Mouse Full Length protein, in the 1 to 175 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
Pap2, Reg3a, Regenerating islet-derived protein 3-alpha, REG-3-alpha, Islet of Langerhans regenerating protein 3, Lithostathine 3, Pancreatitis-associated protein 2, Regenerating islet-derived protein III-alpha, Reg III-alpha
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse Reg3a protein (His tag) (AB276789)
SDS-PAGE analysis of ab276789
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Reg3a acts as an antimicrobial peptide that targets bacterial cell walls specifically binding to peptidoglycans. This ability to bind and break down the cell wall helps in controlling bacterial populations within the gut therefore Reg3a becomes an innate defense component. It works independently and is not known to be part of a larger protein complex. Moreover Reg3a shows bactericidal activity against Gram-positive bacteria contributing to the maintenance of a healthy gut flora.
Pathways
Reg3a functions prominently in the innate immune response and inflammatory pathways. The protein gets upregulated in response to cytokines like Interleukin-22 (IL-22) which helps Reg3a to exert its antimicrobial properties. Reg3a shares relatedness with proteins like Reg3g when considering their roles in the protection of intestinal epithelial barriers. These proteins work together to safeguard the gut lining by destroying harmful bacterial invaders therefore playing an important role in maintaining intestinal integrity.
Specifications
Form
Lyophilized
General info
Function
Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan.. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (By similarity). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed : 22727489). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed : 36240759).
Post-translational modifications
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
Target data
Product promise
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