Recombinant Mouse Reg3b protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Reg3b acts as an antimicrobial peptide that defends the intestinal mucosa from pathogenic invasion. It operates by interacting directly with microbes and affecting their cellular integrity. Reg3b does not exist as part of a larger protein complex but functions independently to execute its defensive role. It is especially active during inflammatory responses in the gut. Enhanced Reg3b expression often occurs due to signals from inflammatory cytokines like IL-22 which is instrumental in the maintenance of intestinal homeostasis.

Pathways

Reg3b plays an important role in the immune pathways related to mucosal immunity and acute phase response. In the IL-22 signaling pathway Reg3b serves as one of the main effector molecules. This pathway is critical during inflammation and recovery processes in the intestines. Reg3b also interacts with proteins involved in the NF-kB signaling pathway which influences the transcription of other defensins and antimicrobial peptides. This alignment with these pathways ensures an effective first line of defense against infections.