Recombinant Mouse RELM Gamma protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Resistin-like molecule gamma (RELM Gamma) also known as RETNLG is a small protein with a molecular mass of approximately 12 kDa. RELM Gamma plays a role in innate immune responses and belongs to the resistin-like molecule family. This protein expresses primarily in the gastrointestinal tract lungs and spleen. Mechanically it functions by modulating inflammation and host-pathogen interactions possibly through the alteration of signaling pathways associated with immune responses.

Biological function summary

RELM Gamma affects several immune system processes. It binds to pattern recognition receptors and influences cytokine secretion which regulates inflammation. RELM Gamma does not form part of a larger protein complex. Its expression often increases in response to microbial infections demonstrating its role in defensive immune mechanisms. Additionally it may modulate the activity of immune cells like macrophages and dendritic cells.

Pathways

RELM Gamma contributes to inflammatory and immune response pathways. It interacts with pathways such as the Toll-like receptor (TLR) signaling pathway and may influence the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway. RELM Gamma also has relationships with proteins like interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) that play roles in these pathways.

RELM Gamma associates with conditions like asthma and inflammatory bowel disease (IBD). In asthma altered expression of RELM Gamma affects airway inflammation. For IBD RELM Gamma may contribute to intestinal inflammation along with proteins such as interleukin 6 (IL-6). Understanding its role in these diseases can aid in developing targeted therapies aimed at regulating its function.