Recombinant Mouse SAA1 protein (Tagged)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Serum amyloid A1 (SAA1) is a small protein with a molecular mass of approximately 12 kDa. Researchers also call it SAA or acute phase serum amyloid protein. Hepatocytes mainly express SAA1 during the acute phase response but some expression occurs in other tissues. SAA1 significantly increases in response to inflammatory stimuli acting as an important player in the body's reaction to injury or infection.

Biological function summary

This protein regulates cholesterol metabolism and serves as a chemoattractant directing cell movement towards the sites of inflammation. SAA1 does not exist alone often associating with high-density lipoproteins (HDL) in circulation. By binding to HDL it can aid in transporting cholesterol from tissues to the liver for excretion linking it with both immunological and metabolic processes.

Pathways

Researchers place SAA1 within the inflammation and immune response strategies. It significantly contributes to the acute-phase response and relates to cytokine signaling pathways. SAA1 interacts with proteins such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which are central to the activation and propagation of inflammatory responses in tissues.

Associated diseases and disorders

SAA1 closely associates with chronic inflammatory conditions and amyloidosis. Excessive SAA1 levels can lead to amyloid A (AA) amyloidosis where protein fragments deposit abnormally in organs. It also plays a role in conditions like rheumatoid arthritis where inflammation perpetuates disease progression. Interestingly SAA1 levels correlate with C-reactive protein (CRP) another marker of inflammation frequent in similar disorders.