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AB235967

Recombinant Mouse SAA1 protein (Tagged)

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Recombinant Mouse SAA1 protein (Tagged) is a Mouse Full Length protein, in the 20 to 122 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Serum amyloid A-1 protein, Saa1

1 Images
SDS-PAGE - Recombinant Mouse SAA1 protein (Tagged) (AB235967)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse SAA1 protein (Tagged) (AB235967)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab235967.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P05366

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Complementary Products

Primary Antibodies

AB201732

Alexa Fluor® 594 Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 594 Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker (AB201732)

  • 0
  • 0
Primary Antibodies

AB190802

Anti-Serum Amyloid A antibody [EP11592-92]

BOND RX™ Validated|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Serum Amyloid A antibody [EP11592-92] (AB190802)

  • 0
  • 1
Proteins & Peptides

AB151645

Recombinant Human Serum Amyloid P/SAP protein

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GFFSFVHEAFQGAGDMWRAYTDMKEANWKNSDKYFHARGNYDAAQRGPGGVWAAEKISDGREAFQEFFGRGHEDTIADQEANRHGRSGKDPNYYRPPGLPDKY","proteinLength":"Full Length","predictedMolecularWeight":"27.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":122,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P05366","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Serum amyloid A1 (SAA1) is a small protein with a molecular mass of approximately 12 kDa. Researchers also call it SAA or acute phase serum amyloid protein. Hepatocytes mainly express SAA1 during the acute phase response but some expression occurs in other tissues. SAA1 significantly increases in response to inflammatory stimuli acting as an important player in the body's reaction to injury or infection.
Biological function summary

This protein regulates cholesterol metabolism and serves as a chemoattractant directing cell movement towards the sites of inflammation. SAA1 does not exist alone often associating with high-density lipoproteins (HDL) in circulation. By binding to HDL it can aid in transporting cholesterol from tissues to the liver for excretion linking it with both immunological and metabolic processes.

Pathways

Researchers place SAA1 within the inflammation and immune response strategies. It significantly contributes to the acute-phase response and relates to cytokine signaling pathways. SAA1 interacts with proteins such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which are central to the activation and propagation of inflammatory responses in tissues.

SAA1 closely associates with chronic inflammatory conditions and amyloidosis. Excessive SAA1 levels can lead to amyloid A (AA) amyloidosis where protein fragments deposit abnormally in organs. It also plays a role in conditions like rheumatoid arthritis where inflammation perpetuates disease progression. Interestingly SAA1 levels correlate with C-reactive protein (CRP) another marker of inflammation frequent in similar disorders.
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Specifications

Form

Liquid

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General info

Function

Major acute phase protein.

Sequence similarities

Belongs to the SAA family.

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Product protocols

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Target data

Major acute phase protein.
See full target information Serum amyloid A-1 protein
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Product promise

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