Recombinant Mouse SAA3 protein is a Mouse Full Length protein, in the 20 to 122 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Yeast
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
R W V Q F M K E A G Q G S R D M W R A Y S D M K K A N W K N S D K Y F H A R G N Y D A A R R G P G G A W A A K V I S D A R E A V Q K F T G H G A E D S R A D Q F A N E W G R S G K D P N H F R P A G L P K R Y
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Major acute phase reactant. Apolipoprotein of the HDL complex. In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity).
Alternative names
Serum amyloid A-3 protein, Saa3
Recommended products
Recombinant Mouse SAA3 protein is a Mouse Full Length protein, in the 20 to 122 aa range, expressed in Yeast, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Yeast
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P04918-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- R W V Q F M K E A G Q G S R D M W R A Y S D M K K A N W K N S D K Y F H A R G N Y D A A R R G P G G A W A A K V I S D A R E A V Q K F T G H G A E D S R A D Q F A N E W G R S G K D P N H F R P A G L P K R Y
- Accession
- P04918
- Protein length
- Full Length
- Amino acids
- 20 to 122
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Major acute phase reactant. Apolipoprotein of the HDL complex. In vitro exhibits antimicrobial activity against Escherichia coli, Streptococcus uberis and Pseudomonas aeruginosa (By similarity).
- Sequence similarities
Belongs to the SAA family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Serum Amyloid A3 (SAA3) is a member of the serum amyloid A family of proteins and is known for its acute-phase response activity. This protein has an approximate mass of 14 kDa. SAA3 expression is mainly found in extrahepatic tissues in response to pro-inflammatory stimuli. It increases quickly during inflammation and tissue injury serving as a sensitive marker for inflammatory diseases. SAA3's function in the immune response makes it an important protein for researchers studying inflammation and related conditions.
- Biological function summary
SAA3 modulates inflammatory responses and may play a role in the pathogenesis of chronic inflammatory diseases. SAA3 proteins can associate with high-density lipoprotein (HDL) in the bloodstream. Such association changes the lipid metabolism and cholesterol transport affecting the body's inflammatory state. The protein also participates in attracting immune cells like leukocytes to the site of inflammation contributing to immune surveillance and tissue repair.
- Pathways
Several studies show that SAA3 participates in the toll-like receptor (TLR) signaling and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways. These pathways are key regulators of the immune response. SAA3 activation can lead to increased cytokine production such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha). Its interactions with other SAAs suggest an overlap in their immune-modulating roles making them important players in systemic inflammation.
- Associated diseases and disorders
SAA3 is linked to conditions like chronic inflammatory diseases and cancer. In rheumatoid arthritis for instance elevated levels of SAA3 correlate with disease severity implicating it as a potential biomarker. The protein is also associated with atherosclerosis where it may influence the development of arterial plaques. Its connection to SAA1 and SAA2 which are also related to inflammation and amyloid deposition highlights a broader role for SAAs in inflammatory and amyloid-related pathologies.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Mouse SAA3 protein (ab238216)
Analysis of of ab238216 by (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com