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AB239571

Recombinant Mouse SCGB3A2 protein (Tagged)

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Recombinant Mouse SCGB3A2 protein (Tagged) is a Mouse Full Length protein, in the 22 to 139 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Pnsp1, Ugrp1, Scgb3a2, Secretoglobin family 3A member 2, Pneumo secretory protein 1, Uteroglobin-related protein 1, PnSP-1

1 Images
SDS-PAGE - Recombinant Mouse SCGB3A2 protein (Tagged) (AB239571)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse SCGB3A2 protein (Tagged) (AB239571)

ab239571 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q920H1

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LLINRLPVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLVIIICSYFPGRSLCYVNNLPSFVSVLFLPMICAYPRDSKKQTFAFIERVFEQSKL","proteinLength":"Full Length","predictedMolecularWeight":"43.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":139,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q920H1","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SCGB3A2 also recognized as uteroglobin-related protein 1 (UGRP1) is a small secreted protein with a molecular mass around 10 kDa. It is mainly expressed in the epithelial cells of the respiratory tract notably the lungs where it plays a role in modulating immune responses. In terms of structure SCGB3A2 shares similarities with other secretoglobin family members indicating conserved functional motifs. Its expression is tightly regulated and reflects its involvement in maintaining respiratory health.
Biological function summary

SCGB3A2 acts as an anti-inflammatory agent that modulates immune cell activity and cytokine signaling within the lungs. It does not form known protein complexes but interacts with other immune mediators to reduce inflammation. Furthermore SCGB3A2 has roles in cell proliferation and repair mechanisms especially in response to lung injury. Its interaction with various cytokines supports tissue regeneration and homeostasis making it important in maintaining lung function.

Pathways

SCGB3A2 interacts in immune regulatory pathways significant in lung tissue. Notably it participates in pathways related to the suppression of inflammatory cytokine production and has a working relationship with proteins such as IL-10 and TGF-beta that mitigate excessive immune reactions. These interactions exhibit roles in the regulation of immune responses and the promotion of tissue repair making SCGB3A2 part of important biological processes that protect lung integrity.

SCGB3A2 is linked to conditions such as asthma and chronic obstructive pulmonary disease (COPD) where inflammation plays an important role. Alterations in SCGB3A2 expression correlate with disease severity suggesting its potential as a biomarker. Its relationship with TGF-beta is of particular interest as dysregulation of this protein contributes to fibrotic changes in lung tissue. Studies continue to explore how modulating SCGB3A2 levels may influence disease progression and treatment outcomes in inflammatory lung disorders.
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Specifications

Form

Liquid

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General info

Function

Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed : 24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed : 16456148, PubMed : 25242865). Also has anti-fibrotic activity in lung (PubMed : 24213919, PubMed : 26559674). May play a role in fetal lung development and maturation (PubMed : 18535256). Promotes branching morphogenesis during early stages of lung development (PubMed : 18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed : 24514953).

Sequence similarities

Belongs to the secretoglobin family. UGRP subfamily.

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Product protocols

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Target data

Secreted cytokine-like protein (By similarity). Binds to the scavenger receptor MARCO (By similarity). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (By similarity). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed : 24213919). Seems to have anti-inflammatory effects in respiratory epithelium (PubMed : 16456148, PubMed : 25242865). Also has anti-fibrotic activity in lung (PubMed : 24213919, PubMed : 26559674). May play a role in fetal lung development and maturation (PubMed : 18535256). Promotes branching morphogenesis during early stages of lung development (PubMed : 18535256). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (PubMed : 24514953).
See full target information Scgb3a2
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