Recombinant Mouse SEMA4A protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 676 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.
M A L P S L G Q D S W S L L R V F F F Q L F L L P S L P P A S G T G G Q G P M P R V K Y H A G D G H R A L S F F Q Q K G L R D F D T L L L S D D G N T L Y V G A R E A V L A L N I Q N P G I P R L K N M I P W P A S E R K K T E C A F K K K S N E T Q C F N F I R V L V S Y N A T H L Y A C G T F A F S P A C T F I E L Q D S L L L P I L I D K V M D G K G Q S P F D P V H K H T A V L V D G M L Y S G T M N N F L G S E P I L M R T L G S Q P V L K T D I F L R W L H A D A S F V A A I P S T Q V V Y F F F E E T A S E F D F F E E L Y I S R V A Q V C K N D V G G E K L L Q K K W T T F L K A Q L L C A Q P G Q L P F N I I R H A V L L P A D S P S V S R I Y A V F T S Q W Q V G G T R S S A V C A F S L T D I E R V F K G K Y K E L N K E T S R W T T Y R G S E V S P R P G S C S M G P S S D K A L T F M K D H F L M D E H V V G T P L L V K S G V E Y T R L A V E S A R G L D G S S H V V M Y L G T S T G S L H K A V V P Q D S S A Y L V E E I Q L S P D S E P V R N L Q L A P A Q G A V F A G F S G G I W R V P R A N C S V Y E S C V D C V L A R D P H C A W D P E S R L C S L L S G S T K P W K Q D M E R G N P E W V C T R G P M A R S P R R Q S P P Q L I K E V L T V P N S I L E L P C P H L S A L A S Y H W S H G R A K I S E A S A T V Y N G S L L L L P Q D G V G G L Y Q C V A T E N G Y S Y P V V S Y W V D S Q D Q P L A L D P E L A G V P R E R V Q V P L T R V G G G A S M A A Q
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Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:17318185, PubMed:20043131). Regulates glutamatergic and GABAergic synapse development (PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988). Promotes phosphorylation of TIMD2 (PubMed:12374982). Inhibits angiogenesis (PubMed:17318185). Promotes axon growth cone collapse (PubMed:20043131). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131).
Semab, SemB, Sema4a, Semaphorin-4A, Semaphorin-B, Sema B
Recombinant Mouse SEMA4A protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 676 aa range, expressed in CHO, with >=98% purity, < 0.06 EU/µg endotoxin level and suitable for SDS-PAGE.
Constituents: 100% PBS
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:17318185, PubMed:20043131). Regulates glutamatergic and GABAergic synapse development (PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988). Promotes phosphorylation of TIMD2 (PubMed:12374982). Inhibits angiogenesis (PubMed:17318185). Promotes axon growth cone collapse (PubMed:20043131). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131).
Belongs to the semaphorin family.
SEMA4A also known as Semaphorin-4A is a protein that functions as a guidance cue in the immune and nervous systems. It has a molecular mass of approximately 85 kDa. SEMA4A is expressed in various tissues including the retina lung and thymus as well as in several immune cells such as T cells B cells and dendritic cells. This protein plays a significant role in cell signaling affecting cellular processes like axonal guidance and immune responses.
The interaction of SEMA4A with its receptors such as Plexin B1 and TIM-2 mediates important cellular activities. It is part of the broader semaphorin family which has a role in directing axonal growth during development. This protein contributes to the regulation of immune cell activity including the activation and differentiation of T cells. The presence of SEMA4A influences immune responses highlighting its importance in maintaining immune system balance.
SEMA4A engages in the immune system and axon guidance pathways. In the immune system it interacts with proteins like Plexin B1 and CD72 influencing T cell proliferation and function. Through the axon guidance pathway SEMA4A helps direct the growth of nerve fibers impacting neuronal circuit formation. These interactions exemplify SEMA4A's role in linking cell signaling with physiological outcomes.
SEMA4A has connections with retinal degenerative diseases and immune system disorders. Mutations in the SEMA4A gene have been associated with retinitis pigmentosa a retinal disorder leading to vision loss. SEMA4A also plays a role in autoimmune diseases where its interaction with receptors like Plexin B1 affects immune cell function. Understanding the involvement of SEMA4A in these conditions helps in developing potential therapeutic approaches targeting its signaling pathways.
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