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AB235970

Recombinant Mouse SFRP5 protein (His tag)

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Recombinant Mouse SFRP5 protein (His tag) is a Mouse Full Length protein, in the 22 to 314 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Secreted frizzled-related protein 5, sFRP-5, Sfrp5

1 Images
SDS-PAGE - Recombinant Mouse SFRP5 protein (His tag) (AB235970)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse SFRP5 protein (His tag) (AB235970)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab235970.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9WU66

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"APTRGQEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAARAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH","proteinLength":"Full Length","predictedMolecularWeight":"37.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9WU66","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SFRP5 also known as Secreted Frizzled-Related Protein 5 is a protein with a mass of approximately 36 kDa. It belongs to the family of secreted frizzled-related proteins that modulate Wnt signaling pathways. This protein acts as a modulator for Wnt ligands by binding to them and preventing their interaction with Frizzled receptors on the cell surface. SFRP5 is particularly expressed in adipose tissues and the retina where it affects processes related to these tissues.
Biological function summary

SFRP5 plays a significant role in cellular growth and differentiation. It acts as an antagonist to the Wnt signaling pathway and helps to maintain tissue homeostasis. By forming a complex with Wnt ligands it regulates the signaling processes important for development and cell proliferation. The inhibitory effect of SFRP5 on Wnt signaling has implications in controlling inflammation and metabolic functions specifically in adipose tissue.

Pathways

SFRP5 is involved in the canonical Wnt signaling pathway and the non-canonical Wnt/planar cell polarity pathway. These pathways are essential in embryonic development and maintaining adult tissue function. SFRP5 interacts with proteins such as beta-catenin in the canonical pathway and influences their downstream effects. These interactions help regulate cellular adhesion and migration which are important during developmental processes and in tissue repair mechanisms.

SFRP5 has been linked to metabolic conditions such as obesity and diabetes. In obesity its regulatory effects on inflammation and metabolism in adipose tissue become significant. SFRP5 works with adiponectin another protein involved in metabolic pathways to influence these conditions. In diabetes changes in SFRP5 expression can impact insulin sensitivity contributing to disease progression. The modulation of Wnt signaling by SFRP5 also has potential implications in tumorigenesis although this area requires further research to fully understand the interactions involved.
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Specifications

Form

Liquid

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General info

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Sequence similarities

Belongs to the secreted frizzled-related protein (sFRP) family.

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Product protocols

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Target data

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
See full target information Sfrp5
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