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AB276920

Recombinant Mouse ST6GAL1 protein (His tag)

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Recombinant Mouse ST6GAL1 protein (His tag) is a Mouse Fragment protein, in the 27 to 403 aa range, expressed in HEK 293 cells, with 95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Siat1, St6gal1, ST6Gal I, Sialyltransferase 1, ST6GalI

1 Images
SDS-PAGE - Recombinant Mouse ST6GAL1 protein (His tag) (AB276920)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse ST6GAL1 protein (His tag) (AB276920)

SDS-PAGE analysis of ab276920

Key facts

Purity

95% HPLC

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q64685

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.5 Constituents: 0.7% Sodium chloride, 0.24% Tris

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"KKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC","proteinLength":"Fragment","predictedMolecularWeight":"45.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":403,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q64685","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST6GAL1 is an enzyme that belongs to the glycosyltransferase family specifically classified as a sialyltransferase. ST6GAL1 catalyzes the addition of sialic acid to glycoproteins and glycolipids impacting their function and stability. It has an approximate molecular mass of 45 kDa. ST6GAL1 is expressed in a variety of cell types including B lymphocytes and epithelial cells. Its expression can be observed on the cell surface where it plays important roles in cell-cell interactions.
Biological function summary

ST6GAL1 contributes to the mechanics of cell signaling and immune system modulation. ST6GAL1 is involved in the biosynthesis of sialylated glycoconjugates which affect cellular recognition and communication. This enzyme does not form part of a multi-protein complex but interacts with other proteins upon glycosylation events. Through its action ST6GAL1 impacts multiple cellular processes including inflammation regulation and pathogen recognition.

Pathways

ST6GAL1 plays roles in glycosylation and immune response mechanisms. It participates in the N-glycan biosynthesis pathway which influences protein folding and stability. Additionally ST6GAL1 impacts the sialylation pathway where it modifies the surface proteins for lymphocyte activation. Importantly ST6GAL1 interacts with proteins such as Siglecs which are involved in immune response modulation and cellular recognition.

ST6GAL1 is implicated in cancer progression and autoimmune diseases. In various cancers such as colon cancer altered ST6GAL1 expression affects metastatic potential and tumor cell survival. Additionally aberrant ST6GAL1 expression occurs in autoimmune diseases like lupus wherein it modulates immune cell activity. ST6GAL1 interacts with proteins like CD22 a sialic acid-binding lectin on B cells influencing disease pathogenesis and progression through immune system pathways.
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Specifications

Form

Lyophilized

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General info

Function

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.. N-glycosylated.

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Product protocols

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Target data

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
See full target information St6gal1
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