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AB276927

Recombinant Mouse ST6GALNAC2 protein

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Recombinant Mouse ST6GALNAC2 protein is a Mouse Fragment protein, in the 28 to 373 aa range, expressed in HEK 293 cells, with >98%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Siat7, Siat7b, St6galnac2, ST6GalNAc II, Sialyltransferase 7B, ST6GalNAcII, SIAT7-B

1 Images
SDS-PAGE - Recombinant Mouse ST6GALNAC2 protein (AB276927)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse ST6GALNAC2 protein (AB276927)

SDS-PAGE analysis of ab276927

Key facts

Purity

>98% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P70277

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ST6GalNAc I antibody (AB229816)

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SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

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Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"SAGQQSPETQVPARNMAYPRAFFDPKPPNSENRKSRLCQHSLSLAIQKDRRFRSLFDLSTPVLLWEGLFTQELWNNLSQHKVPYGWQGLSHEVIASTLRLLKSPESGELFGAPRKLPLSCIRCAVVGNGGILNGSRQGQKIDAHDYVFRLNGAITEGFERDVGTKTSFYGFTVNTMKNSLISYAKLGFTSVPQGQNLRYIFIPSSIRDYLMLRSAILGVPVPEGPDKGDRPHTYFGPETSASKFKLLHPDFISYLTERFLKSKLINTRFGDMYMPSTGALMLLTALHTCDQVSAYGFITNNYQKYSDHYFEREKKPLIFYANHDLSLEASLWRDLHNAGILWLYQR","proteinLength":"Fragment","predictedMolecularWeight":"40.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P70277","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ST6GALNAC2 also known as GalNAc α-26-sialyltransferase 2 is an enzyme involved in the sialylation process. Its molecular mass is approximately 56 kDa. The enzyme is expressed prominently in human tissues like the colon small intestine and spleen. ST6GALNAC2 catalyzes the transfer of sialic acid from CMP-NeuAc to GalNAc residues of glycoproteins and glycolipids playing a role in modifying their structures.
Biological function summary

The enzyme has a significant role in the biosynthesis of sialylated structures influencing cell-cell interactions signaling and immune modulation. ST6GALNAC2 is part of the glycosyltransferase family and it acts without forming larger complexes. Its activity affects the surface glycosylation pattern of cells influencing properties like cell adhesion and signaling pathways that are critical for cellular communication.

Pathways

Sialylation influences cellular interactions and immune responses and ST6GALNAC2's addition of sialic acid units impacts these processes. It participates in the glycosphingolipid biosynthesis pathway and influences the sialylation branch of the Nglycosylation pathway. ST6GALNAC2's activities interplay with other sialyltransferases in regulating the sialylation state of glycoproteins affecting interactions with receptors such as selectins and integrins which are important in mediating cellular adhesion and trafficking.

Altered ST6GALNAC2 activity links to colorectal cancer and inflammatory bowel diseases. In colorectal cancer modifications in glycosylation patterns influenced by ST6GALNAC2 and related enzymes like ST6GALNAC1 correlate with tumor progression and metastasis. In inflammatory bowel diseases the enzyme contributes to changes in the mucosal barrier affecting immune responses and tissue integrity. Understanding ST6GALNAC2's role offers insights into therapeutic targets in these diseases.
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General info

Function

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 8662927). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 8662927).

Sequence similarities

Belongs to the glycosyltransferase 29 family.

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Product protocols

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Target data

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 8662927). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 8662927).
See full target information St6galnac2
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