Recombinant Mouse SULT1A1/STP protein (Tagged) is a Mouse Full Length protein, in the 1 to 291 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M E P L R K P L V P V K G I P L I K Y F A E T M E Q L Q N F T A W P D D V L I S T Y P K S G T N W M S E I M D M I Y Q G G K L D K C G R A P V Y A R I P F L E F S C P G V P P G L E T L K E T P A P R I I K T H L P L S L L P Q S L L D Q K I K V I Y V A R N A K D V V V S Y Y N F Y K M A K L H P D P G T W E S F L E N F M D G K V S Y G S W Y Q H V K E W W E L R R T H P V L Y L F Y E D M K E N P K R E I K K I L E F L G R S L P E E T V D L I V H H T S F K K M K E N P M A N Y T T I P T E V M D H T I Y P F M R K G T I G D W K N T F T V A Q S E H F D A H Y A K L M T G C D F T F R C Q I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Alternative names
St1a1, Stp, Stp1, Sult1a1, Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase, Phenol sulfotransferase, Phenol/aryl sulfotransferase, ST1A4, Sulfokinase, mSTp1
Recommended products
Recombinant Mouse SULT1A1/STP protein (Tagged) is a Mouse Full Length protein, in the 1 to 291 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P52840-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M E P L R K P L V P V K G I P L I K Y F A E T M E Q L Q N F T A W P D D V L I S T Y P K S G T N W M S E I M D M I Y Q G G K L D K C G R A P V Y A R I P F L E F S C P G V P P G L E T L K E T P A P R I I K T H L P L S L L P Q S L L D Q K I K V I Y V A R N A K D V V V S Y Y N F Y K M A K L H P D P G T W E S F L E N F M D G K V S Y G S W Y Q H V K E W W E L R R T H P V L Y L F Y E D M K E N P K R E I K K I L E F L G R S L P E E T V D L I V H H T S F K K M K E N P M A N Y T T I P T E V M D H T I Y P F M R K G T I G D W K N T F T V A Q S E H F D A H Y A K L M T G C D F T F R C Q I
- Accession
- P52840
- Protein length
- Full Length
- Predicted molecular weight
- 54 kDa
- Amino acids
- 1 to 291
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
- Sequence similarities
Belongs to the sulfotransferase 1 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as SULT1A1
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SULT1A1 also known as STP is an enzyme that plays an important role in the metabolism of various hormones drugs and other xenobiotic compounds. It belongs to the sulfotransferase family responsible for catalyzing the sulfate conjugation of many endogenous and exogenous compounds. SULT1A1 has a molecular mass of approximately 34 kDa. The enzyme is highly expressed in the liver but is also found in other tissues like the intestine and lung. It facilitates the transfer of a sulfo group from the universal sulfate donor 3’-phosphoadenosine-5’-phosphosulfate (PAPS) to substrates such as phenolic compounds.
- Biological function summary
The enzyme contributes significantly to the detoxification and activation of its substrates in the body. SULT1A1 functions without being part of a larger protein complex allowing it direct interaction with its substrates. By modifying hormones such as estrogens and catecholamines it helps regulate their activity and half-life. Additionally SULT1A1 plays a role in the metabolic processing of drugs influencing their pharmacokinetics and pharmacodynamics.
- Pathways
SULT1A1 is a critical component of both the phenolic metabolism pathway and the metabolism of xenobiotics by cytochrome P450. These pathways involve other proteins like CYP2C9 and GSTP1 which participate in further detoxification and conjugation reactions. Within these pathways SULT1A1 contributes to the inactivation or activation of compounds altering their biological activity and facilitating their excretion from the body.
- Associated diseases and disorders
SULT1A1 has been associated with variable drug responses and certain cancers. Altered activity of this enzyme can influence clearance of drugs potentially leading to adverse drug reactions or therapeutic failure. Moreover the dysregulation of estrogen metabolism partly mediated by SULT1A1 may contribute to hormone-related cancers such as breast cancer. The enzyme's interaction with proteins like UGT1A1 within these disease contexts highlights its role in the broader framework of metabolic processes impacting health and disease outcomes.
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3 product images
SDS-PAGE - Recombinant Mouse SULT1A1/STP protein (Tagged) (ab236328)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab236328.
Mass Spectrometry - Recombinant Mouse SULT1A1/STP protein (Tagged) (ab236328)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab236328 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) SULT1A1/STP.
Mass Spectrometry - Recombinant Mouse SULT1A1/STP protein (Tagged) (ab236328)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab236328 could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) SULT1A1/STP.
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