Recombinant Mouse Syndecan 2/HSPG protein (His tag) is a Mouse Fragment protein, in the 1 to 141 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M Q R A W I L L T L G L M A C V S A E T R T E L T S D K D M Y L D N S S I E E A S G V Y P I D D D D Y S S A S G S G A D E D I E S P V L T T S Q L I P R I P L T S A A S P K V E T M T L K T Q S I T P A Q T E S P E E T D K E E V D I S E A E E K L G P A I K S T D V Y T E K H S D N L F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
Alternative names
CD362, Hspg1, Synd2, Sdc2, Syndecan-2, SYND2, Fibroglycan, Heparan sulfate proteoglycan core protein, HSPG
Recommended products
Recombinant Mouse Syndecan 2/HSPG protein (His tag) is a Mouse Fragment protein, in the 1 to 141 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P43407-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M Q R A W I L L T L G L M A C V S A E T R T E L T S D K D M Y L D N S S I E E A S G V Y P I D D D D Y S S A S G S G A D E D I E S P V L T T S Q L I P R I P L T S A A S P K V E T M T L K T Q S I T P A Q T E S P E E T D K E E V D I S E A E E K L G P A I K S T D V Y T E K H S D N L F
- Accession
- P43407
- Protein length
- Fragment
- Predicted molecular weight
- 14.8 kDa
- Amino acids
- 1 to 141
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Cell surface proteoglycan which regulates dendritic arbor morphogenesis.
- Sequence similarities
Belongs to the syndecan proteoglycan family.
- Post-translational modifications
O-glycosylated; contains both heparan sulfate and chondroitin sulfate.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Syndecan-2 also known as HSPG (Heparan Sulfate Proteoglycan) protein is a cell surface proteoglycan commonly found in many tissues. It weighs approximately 48- to 50-kDa. Syndecan-2 has a transmembrane core protein and is characterized by the attachment of heparan sulfate glycosaminoglycan chains. It expresses in various cell types including fibroblasts epithelial cells and neuronal cells. This protein binds to extracellular matrix components and growth factors following its structural attributes.
- Biological function summary
Syndecan-2 interacts with multiple partners to regulate cellular processes. It is often part of a larger complex involving extracellular matrix proteins and growth factors. Syndecan-2 modulates cytoskeleton organization cell adhesion and migration. Its activity plays significant roles in tissue repair and development because of its involvement in signal transduction via these interactions. Numerous research studies suggest its regulatory impact on cell morphology and signaling events.
- Pathways
Syndecan-2 is heavily implicated in several important biological signaling cascades. The protein significantly influences the Wnt signaling pathway which governs cell proliferation differentiation and migration. Another key pathway involving Syndecan-2 is the Rho family of GTPase pathway where it interacts with proteins like Rac1 and Cdc42 to mediate actin cytoskeleton dynamics. These pathways associate Syndecan-2 with cellular responses to extracellular signals contributing to its role in tissue homeostasis.
- Associated diseases and disorders
Syndecan-2 expressions and functions associate with tumor growth and metastasis particularly in cancers such as colorectal and breast cancer. The protein affects tumor microenvironment remodeling facilitating cancerous invasion and dissemination. Additionally Syndecan-2 links to inflammatory diseases like atherosclerosis where it contributes to vascular damage and inflammation. In these conditions Syndecan-2 interactions with other proteins such as integrins exacerbate pathogenic processes.
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1 product image
SDS-PAGE - Recombinant Mouse Syndecan 2/HSPG protein (His tag) (ab276969)
SDS-PAGE analysis of ab276969
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