Recombinant Mouse TAG1/TAX1 protein (His tag) is a Mouse Fragment protein, in the 31 to 1013 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
Q G T P A T F G P V F E E Q P V G L L F P E E S A E D Q V T L A C R A R A S P P A T Y R W K M N G T E M N L E P G S R H Q L M G G N L V I M S P T K A Q D A G V Y Q C L A S N P V G T V V S K E A V L R F G F L Q E F S K E E R D P V K T H E G W G V M L P C N P P A H Y P G L S Y R W L L N E F P N F I P T D G R H F V S Q T T G N L Y I A R T N A S D L G N Y S C L A T S H L D F S T K S V F S K F A Q L N L A A E D P R L F A P S I K A R F P P E T Y A L V G Q Q V T L E C F A F G N P V P R I K W R K V D G S L S P Q W G T A E P T L Q I P S V S F E D E G T Y E C E A E N S K G R D T V Q G R I I V Q A Q P E W L K V I S D T E A D I G S N L R W G C A A A G K P R P M V R W L R N G E P L A S Q N R V E V L A G D L R F S K L N L E D S G M Y Q C V A E N K H G T I Y A S A E L A V Q A L A P D F R Q N P V R R L I P A A R G G E I S I P C Q P R A A P K A T I L W S K G T E I L G N S T R V T V T L D G T L I I R N I S R S D E G K Y T C F A E N F M G K A N S T G I L S V R D A T K I T L A P S S A D I N V G D N L T L Q C H A S H D P T M D L T F T W T L D D F P V D F D K P G G H Y R R A S V K E T I G D L T I L N A Q L R H G G T Y T C M A Q T V V D G A S K E A T V L V R G P P G P P G G V V V R D I G D T T V Q L S W S R G F D N H S P I A K Y T L Q A R T P P S G K W K Q V R T N P V N I E G N A E T A Q V L G L M P W M D Y E F R V S A S N I L G T G E P S G P S S R I R T K E A V P S V A P S G L S G G G G A P G E L T I N W T P M S R E Y Q N G D G F G Y L L S F R R Q G S S S W Q T A R V P G A D T Q Y F V Y S N D S I H P Y T P F E V K I R S Y N R R G D G P E S L T A I V Y S A E E E P K V A P A K V W A K G S S S S E M N V S W E P V L Q D M N G I L L G Y E I R Y W K A G D K E A A A D R V R T A G L D S S A R V T G L Y P N T K Y H V T V R A Y N R A G T G P A S P S A D A M T M K P P P R R P P G N I S W T F S S S S L S L K W D P V V P L R N E S T V T G Y K M L Y Q N D L Q P T P M L H L T S K N W I E I P V P E D I G H A L V Q I R T T G P G G D G I P A E V H I V R N G G T S M M V E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.
Alternative names
Tax, Cntn2, Contactin-2, Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, TAX-1
Recommended products
Recombinant Mouse TAG1/TAX1 protein (His tag) is a Mouse Fragment protein, in the 31 to 1013 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q61330-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- Q G T P A T F G P V F E E Q P V G L L F P E E S A E D Q V T L A C R A R A S P P A T Y R W K M N G T E M N L E P G S R H Q L M G G N L V I M S P T K A Q D A G V Y Q C L A S N P V G T V V S K E A V L R F G F L Q E F S K E E R D P V K T H E G W G V M L P C N P P A H Y P G L S Y R W L L N E F P N F I P T D G R H F V S Q T T G N L Y I A R T N A S D L G N Y S C L A T S H L D F S T K S V F S K F A Q L N L A A E D P R L F A P S I K A R F P P E T Y A L V G Q Q V T L E C F A F G N P V P R I K W R K V D G S L S P Q W G T A E P T L Q I P S V S F E D E G T Y E C E A E N S K G R D T V Q G R I I V Q A Q P E W L K V I S D T E A D I G S N L R W G C A A A G K P R P M V R W L R N G E P L A S Q N R V E V L A G D L R F S K L N L E D S G M Y Q C V A E N K H G T I Y A S A E L A V Q A L A P D F R Q N P V R R L I P A A R G G E I S I P C Q P R A A P K A T I L W S K G T E I L G N S T R V T V T L D G T L I I R N I S R S D E G K Y T C F A E N F M G K A N S T G I L S V R D A T K I T L A P S S A D I N V G D N L T L Q C H A S H D P T M D L T F T W T L D D F P V D F D K P G G H Y R R A S V K E T I G D L T I L N A Q L R H G G T Y T C M A Q T V V D G A S K E A T V L V R G P P G P P G G V V V R D I G D T T V Q L S W S R G F D N H S P I A K Y T L Q A R T P P S G K W K Q V R T N P V N I E G N A E T A Q V L G L M P W M D Y E F R V S A S N I L G T G E P S G P S S R I R T K E A V P S V A P S G L S G G G G A P G E L T I N W T P M S R E Y Q N G D G F G Y L L S F R R Q G S S S W Q T A R V P G A D T Q Y F V Y S N D S I H P Y T P F E V K I R S Y N R R G D G P E S L T A I V Y S A E E E P K V A P A K V W A K G S S S S E M N V S W E P V L Q D M N G I L L G Y E I R Y W K A G D K E A A A D R V R T A G L D S S A R V T G L Y P N T K Y H V T V R A Y N R A G T G P A S P S A D A M T M K P P P R R P P G N I S W T F S S S S L S L K W D P V V P L R N E S T V T G Y K M L Y Q N D L Q P T P M L H L T S K N W I E I P V P E D I G H A L V Q I R T T G P G G D G I P A E V H I V R N G G T S M M V E
- Accession
- Q61330
- Protein length
- Fragment
- Predicted molecular weight
- 108.7 kDa
- Amino acids
- 31 to 1013
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.
- Sequence similarities
Belongs to the immunoglobulin superfamily. Contactin family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TAG1 also known as TAX1 or contactin-2 is a protein encoded by the CNTN2 gene in humans. It is a member of the immunoglobulin superfamily and has a mass of approximately 140 kDa. TAG1 is expressed in the nervous system particularly in the peripheral and central nervous systems during development. It is predominantly found on neurons influencing axonal guidance and neuronal connectivity.
- Biological function summary
TAG1 plays a fundamental role in the nervous system by mediating cell adhesion and signaling. It forms part of a complex often interacting with other cell adhesion molecules to facilitate cellular communication and neurite outgrowth. By influencing neuronal positioning and patterning TAG1 contributes to the proper formation of neural circuits.
- Pathways
There is a strong involvement of TAG1 in axonal growth and guidance pathways as well as in the cell adhesion signaling pathway. It directly interacts with proteins such as Caspr and neurofascin which are critical for myelination and the maintenance of the node of Ranvier. These interactions help guide neuron development and function.
- Associated diseases and disorders
Altered expression of TAG1 has been linked to several neural disorders including autism spectrum disorders and schizophrenia. In the context of these diseases TAG1 interacts with other proteins such as contactin-associated protein 1 (Caspr1) which plays an important role in maintaining neural network stability and function. Understanding these interactions provides insights into the pathogenesis of these neurological conditions.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Mouse TAG1/TAX1 protein (His tag) (ab276982)
SDS-PAGE analysis of ab276982
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com