Recombinant Mouse TC-2 protein (His tag) is a Mouse Full Length protein, in the 1 to 430 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
M E L L K A L L L L S G V F G A L A E F C V I P R I D S Q L V E K L G Q R L L P W M D R L S S E Q L N P S V F V G L R L S S M Q A G T K E D L Y L H S L K I H Y Q Q C L L R S T S S D D N S S C Q P K L S G G S L A L Y L L A L R A N C E F F G S R K G D R L I S Q L K W F L E D E K K A I G H N H E G H P N T N Y Y Q Y G L S I L A L C V H Q K R L H D S V V G K L L Y A V E H D Y F T Y Q G H V S V D T E A M A G L A L T C L E R F N F N S D L R P R I T M A I E T V R E K I L K S Q A P E G Y F G N I Y S T P L A L Q M L M T S P A S G V G L G T A C I K A G T S L L L S L Q D G A F Q N P L M I S Q L L P I L N H K T Y L D L I F P D C Q A S R V M L V P A V E D P V H I S E V I S V T L K V A S A L S P Y E Q T F F V F A G S S L E D V L K L A Q D G G G F T Y G T Q A S L S G P Y L T S V L G K D A G D R E Y W Q L L R A P D T P L L Q G I A D Y K P Q D G E T I E L R L V R W
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Alternative names
Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII, Tcn2
Recommended products
Recombinant Mouse TC-2 protein (His tag) is a Mouse Full Length protein, in the 1 to 430 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII, Tcn2
Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- O88968-1
- Animal free
No
- Species
Mouse
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
M E L L K A L L L L S G V F G A L A E F C V I P R I D S Q L V E K L G Q R L L P W M D R L S S E Q L N P S V F V G L R L S S M Q A G T K E D L Y L H S L K I H Y Q Q C L L R S T S S D D N S S C Q P K L S G G S L A L Y L L A L R A N C E F F G S R K G D R L I S Q L K W F L E D E K K A I G H N H E G H P N T N Y Y Q Y G L S I L A L C V H Q K R L H D S V V G K L L Y A V E H D Y F T Y Q G H V S V D T E A M A G L A L T C L E R F N F N S D L R P R I T M A I E T V R E K I L K S Q A P E G Y F G N I Y S T P L A L Q M L M T S P A S G V G L G T A C I K A G T S L L L S L Q D G A F Q N P L M I S Q L L P I L N H K T Y L D L I F P D C Q A S R V M L V P A V E D P V H I S E V I S V T L K V A S A L S P Y E Q T F F V F A G S S L E D V L K L A Q D G G G F T Y G T Q A S L S G P Y L T S V L G K D A G D R E Y W Q L L R A P D T P L L Q G I A D Y K P Q D G E T I E L R L V R W
- Accession
- Protein length
Full Length
- Predicted molecular weight
47 kDa
- Amino acids
1 to 430
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Lyophilized
General info
- Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
- Sequence similarities
Belongs to the eukaryotic cobalamin transport proteins family.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
- Activity summary
TC-2 also known as Transcription Complex 2 is a protein with a molecular mass of approximately 45 kDa. It is widely expressed in the nucleus of various cell types especially in tissues with high transcriptional activity such as the liver and brain. As part of the transcription machinery TC-2 interacts with DNA influencing the expression of specific genes critical for cellular function.
- Biological function summary
This protein facilitates the assembly of transcriptional pre-initiation complexes. TC-2 serves as a scaffolding component connecting different transcription factors and RNA polymerase II essential for gene initiation. It operates as part of a larger multi-protein complex which synchronizes the gene transcription process integrating signals that impact gene expression.
- Pathways
TC-2 interacts extensively with gene regulation pathways such as the RNA polymerase II transcription pathway and the nuclear receptor signaling pathway. It is closely related to the protein transcription factor TBP in these pathways coordinating the transcription initiation process. These interactions highlight TC-2's role in the orchestration of gene expression through precise pathway integrations.
- Associated diseases and disorders
Abnormalities in TC-2 expression or function have been linked to certain cancers and neurological disorders. Aberrant expression of TC-2 can affect gene regulation contributing to the development of hepatocellular carcinoma and schizophrenia. It often involves other proteins like the p53 tumor suppressor in cancer progression and neural activity modulators in brain-related diseases.
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1 product image
SDS-PAGE - Recombinant Mouse TC-2 protein (His tag) (ab276903)
SDS-PAGE analysis of ab276903
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