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AB267838

Recombinant Mouse Tenascin protein

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Recombinant Mouse Tenascin protein is a Mouse Fragment protein, in the 1884 to 2099 aa range, expressed in Mammalian, with >90%, suitable for SDS-PAGE.

View Alternative Names

Hxb, Tnc, Tenascin, TN, Hexabrachion, Tenascin-C, TN-C

1 Images
SDS-PAGE - Recombinant Mouse Tenascin protein (AB267838)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Mouse Tenascin protein (AB267838)

SDS-PAGE analysis of recombinant tenascin protein (ab267838)

Key facts

Purity

>90% SDS-PAGE

Expression system

Mammalian

Tags

10x His tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q80YX1

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.2 - 7.4 Constituents: PBS, 6% Trehalose

storage-buffer

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Complementary Products

Primary Antibodies

AB108930

Anti-Tenascin C antibody [EPR4219]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-Tenascin C antibody [EPR4219] (AB108930)

  • 4
  • 17
Primary Antibodies

AB155034

Anti-TNR antibody

Immunocytochemistry/ Immunofluorescence - Anti-TNR antibody (AB155034)

  • 0
  • 0
Proteins & Peptides

AB276530

Recombinant Human TNRC5 protein (His tag)

SDS-PAGE - Recombinant Human TNRC5 protein (His tag) (AB276530)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSN","proteinLength":"Fragment","predictedMolecularWeight":"241 kDa","actualMolecularWeight":null,"aminoAcidEnd":2099,"aminoAcidStart":1884,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"Q80YX1","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tenascin also known as tenascin-C is a large extracellular matrix glycoprotein with a molecular mass around 210-300 kDa. It exists mainly in tissues undergoing remodeling and in regions of high cellular activity. This includes areas like embryonic tissue healing wounds and certain tumor microenvironments. Notably tenascin presence fluctuates in adult tissues appearing significantly during stress or repair phases.
Biological function summary

Tenascin influences cell adhesion migration and proliferation. It belongs to a complex involving multiple domains that interact with cell surface receptors and other matrix components. The protein gains importance in modulating cell interactions with the extracellular matrix affecting processes such as tissue morphogenesis and cancer metastasis.

Pathways

Tenascin impacts cellular pathways linked to development and tissue repair. It plays roles in the integrin and TGF-beta signaling pathways. These pathways relate tenascin to other proteins like fibronectin and laminin influencing cellular dynamics by affecting structural integrity and signaling cascades.

Connections between tenascin and cancer as well as fibrotic diseases emerge clearly. Elevated tenascin levels appear in several malignancies aiding in tumor progression and immune evasion. Moreover in fibrotic conditions such as liver fibrosis tenascin interacts with proteins like collagen contributing to excessive scar tissue formation and impaired organ function.
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Specifications

Form

Liquid

Additional notes

nan

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General info

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8 : ITGB1, ITGA9 : ITGB1, ITGAV : ITGB3 and ITGAV : ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).

Sequence similarities

Belongs to the tenascin family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8 : ITGB1, ITGA9 : ITGB1, ITGAV : ITGB3 and ITGAV : ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
See full target information Tnc
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Product promise

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