Recombinant Mouse Tenascin protein is a Mouse Fragment protein, in the 1884 to 2099 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
G L L Y P F P R D C S Q A M L N G D T T S G L Y T I Y I N G D K T Q A L E V Y C D M T S D G G G W I V F L R R K N G R E D F Y R N W K A Y A A G F G D R R E E F W L G L D N L S K I T A Q G Q Y E L R V D L Q D H G E S A Y A V Y D R F S V G D A K S R Y K L K V E G Y S G T A G D S M N Y H N G R S F S T Y D K D T D S A I T N C A L S Y K G A F W Y K N C H R V N L M G R Y G D N N H S Q G V N W F H W K G H E Y S I Q F A E M K L R P S N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
Alternative names
Hxb, Tnc, Tenascin, TN, Hexabrachion, Tenascin-C, TN-C
Recommended products
Recombinant Mouse Tenascin protein is a Mouse Fragment protein, in the 1884 to 2099 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Mammalian
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q80YX1-1
- Animal free
- No
- Species
- Mouse
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: PBS, 6% Trehalose
Sequence info
Amino acid sequence
- G L L Y P F P R D C S Q A M L N G D T T S G L Y T I Y I N G D K T Q A L E V Y C D M T S D G G G W I V F L R R K N G R E D F Y R N W K A Y A A G F G D R R E E F W L G L D N L S K I T A Q G Q Y E L R V D L Q D H G E S A Y A V Y D R F S V G D A K S R Y K L K V E G Y S G T A G D S M N Y H N G R S F S T Y D K D T D S A I T N C A L S Y K G A F W Y K N C H R V N L M G R Y G D N N H S Q G V N W F H W K G H E Y S I Q F A E M K L R P S N
- Accession
- Q80YX1
- Protein length
- Fragment
- Predicted molecular weight
- 241 kDa
- Amino acids
- 1884 to 2099
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
nan
General info
- Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
- Sequence similarities
Belongs to the tenascin family.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Tenascin also known as tenascin-C is a large extracellular matrix glycoprotein with a molecular mass around 210-300 kDa. It exists mainly in tissues undergoing remodeling and in regions of high cellular activity. This includes areas like embryonic tissue healing wounds and certain tumor microenvironments. Notably tenascin presence fluctuates in adult tissues appearing significantly during stress or repair phases.
- Biological function summary
Tenascin influences cell adhesion migration and proliferation. It belongs to a complex involving multiple domains that interact with cell surface receptors and other matrix components. The protein gains importance in modulating cell interactions with the extracellular matrix affecting processes such as tissue morphogenesis and cancer metastasis.
- Pathways
Tenascin impacts cellular pathways linked to development and tissue repair. It plays roles in the integrin and TGF-beta signaling pathways. These pathways relate tenascin to other proteins like fibronectin and laminin influencing cellular dynamics by affecting structural integrity and signaling cascades.
- Associated diseases and disorders
Connections between tenascin and cancer as well as fibrotic diseases emerge clearly. Elevated tenascin levels appear in several malignancies aiding in tumor progression and immune evasion. Moreover in fibrotic conditions such as liver fibrosis tenascin interacts with proteins like collagen contributing to excessive scar tissue formation and impaired organ function.
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1 product image
SDS-PAGE - Recombinant Mouse Tenascin protein (ab267838)
SDS-PAGE analysis of recombinant tenascin protein (ab267838)
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