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AB276836

Recombinant Mouse THSD1 protein (His tag)

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Recombinant Mouse THSD1 protein (His tag) is a Mouse Fragment protein, in the 1 to 412 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Tmtsp, Thsd1, Thrombospondin type-1 domain-containing protein 1, Transmembrane molecule with thrombospondin module

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SDS-PAGE - Recombinant Mouse THSD1 protein (His tag) (AB276836)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse THSD1 protein (His tag) (AB276836)

SDS-PAGE analysis of ab276836

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9JM61

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKPMLKDFSNLLLVVLCDYVLGEAEYLLLQEPVHVALSDRTVSVGFHYLSDVNGTLRNVSVMLWEANTNRTLTTKYLLTNQAQGTLQFECFYFKEAGDYWFVMIPEVTDNGTQVPLWEKSAFLKVEWPVFHIDLNRTAKAAEGTFQVGVFTTQPLCLFPVDKPDMLVDVIFTDRLPEARASLGQPLEIRASKRTKLTQGQWVEFGCAPVGVEAYVTVMLRLLGQDSVIASTGPIDLAQKFGYKLMMAPEVTCESVLEVMVLPPPCVFVQGVLAVYKEAPKRPEERTFQVAENRLPLGERRTVFNCTLFDVGKNKYCFNFGIVKKGHFSAKECMLIQRNIETWGPWQPWSPCSTTCGDAVRERRRLCVTSFPSRPSCSGMSSETSPCSLEECAVFRPPGPSPVSPQDPVKSNN","proteinLength":"Fragment","predictedMolecularWeight":"45 kDa","actualMolecularWeight":null,"aminoAcidEnd":412,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9JM61","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THSD1 also known as Thrombospondin Type 1 Domain Containing Protein 1 is a protein encoded by the THSD1 gene. It weighs approximately 75 kDa. THSD1 is expressed in various tissues including vascular endothelial cells and certain regions of the brain. This protein contains thrombospondin type 1 repeats that suggest its involvement in cell-matrix interactions and cellular adhesion processes.
Biological function summary

THSD1 plays a role in cell adhesion and migration. It is involved in blood vessel development and maintenance influencing angiogenesis. THSD1 interacts within the extracellular matrix and may form part of larger adhesion complexes though its exact partners in these complexes require further study. It affects cellular communication and structural organization by binding to other extracellular or membrane proteins.

Pathways

THSD1 participates in cellular adhesion and vascular development pathways. In the angiogenesis pathway it works alongside proteins like VEGF and integrins contributing to endothelial cell function and new blood vessel formation. It has ties to signaling pathways impacting endothelial cell survival and proliferation highlighting its significance in vascular biology.

Mutations or altered expression of THSD1 associate with hereditary hemorrhagic telangiectasia (HHT) and certain cancers including glioblastoma. It links with proteins like endoglin and ALK1 in the context of HHT where it may impact the vascular malformations characteristic of the disease. In cancer its role in cell adhesion and migration can influence tumor progression and metastasis.
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Specifications

Form

Lyophilized

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General info

Function

Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.

Subcellular localisation

Endosome membrane

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Product protocols

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Target data

Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
See full target information Thsd1
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Complementary Products

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AB249268

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