Recombinant Mouse Tim 2 protein (Fc Chimera) is a Mouse Fragment protein, in the 22 to 229 aa range, expressed in HEK 293, with >98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE.
>98% SDS-PAGE
< 5 EU/mg
HEK 293 cells
Tag free
SDS-PAGE
No
H T A V Q G L A G H P V T L P C I Y S T H L G G I V P M C W G L G E C R H S Y C I R S L I W T N G Y T V T H Q R N S L Y Q L K G N I S E G N V S L T I E N T V V G D G G P Y C C V V E I P G A F H F V D Y M L E V K P E I S T S P P T R P T A T G R P T T I S T R S T H V P T S T R V S T S T S P T P A H T E T Y K P E A T T F Y P D Q T T A E V T E T L P D T P A D W H N T V T S S D D P W D D N T E V I P P Q K P Q K N L N
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823). Plays also an important role in the regulation of Th2 immunity (PubMed:16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Tim2, Timd2, Tim2, T-cell immunoglobulin and mucin domain-containing protein 2, TIMD-2, T-cell immunoglobulin mucin receptor 2, T-cell membrane protein 2, TIM-2
Recombinant Mouse Tim 2 protein (Fc Chimera) is a Mouse Fragment protein, in the 22 to 229 aa range, expressed in HEK 293, with >98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE.
>98% SDS-PAGE
< 5 EU/mg
HEK 293 cells
Tag free
SDS-PAGE
No
No
Mouse
Reconstitute vial with 100 µL sterile water. Working aliquots are stable for up to 3 months when stored at -20°C.
Constituents: PBS
H T A V Q G L A G H P V T L P C I Y S T H L G G I V P M C W G L G E C R H S Y C I R S L I W T N G Y T V T H Q R N S L Y Q L K G N I S E G N V S L T I E N T V V G D G G P Y C C V V E I P G A F H F V D Y M L E V K P E I S T S P P T R P T A T G R P T T I S T R S T H V P T S T R V S T S T S P T P A H T E T Y K P E A T T F Y P D Q T T A E V T E T L P D T P A D W H N T V T S S D D P W D D N T E V I P P Q K P Q K N L N
Fragment
65 kDa
22 to 229
Recombinant
Lyophilized
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823). Plays also an important role in the regulation of Th2 immunity (PubMed:16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Belongs to the immunoglobulin superfamily. TIM family.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
T-cell immunoglobulin and mucin domain 2 (Tim-2) also known as HAVCR2 is a protein with a molecular mass of approximately 80 kDa. Tim-2 expresses mainly in the immune system particularly in T cells B cells and dendritic cells. It acts as a receptor with a potential role in regulating the immune response. Tim-2 also presents in various tissues including the liver and kidney suggesting its involvement in multiple physiological processes.
Tim-2 plays an important role in immune regulation and functions as a part of the broader family of T-cell immunoglobulin and mucin domain proteins. It does not typically form part of a complex but interacts with phosphatidylserine a phospholipid exposed during cell apoptosis. This interaction suggests Tim-2 has roles in recognizing apoptotic cells and may influence their removal by macrophages. Additionally it affects lymphocyte activity possibly by modulating T-cell proliferation and cytokine release.
Tim-2 influences immune responses and cell survival pathways. It connects to the phosphatidylserine-mediated clearance pathway a critical component of maintaining tissue homeostasis and preventing inflammation by promoting the clearance of dying cells. Tim-2 also interacts with related proteins such as Tim-3 which shares similar ligand-binding properties and roles in immune response modulation.
Tim-2 relates to its role in immune system regulation and its connection to inflammatory disorders and autoimmune diseases. It is implicated in conditions like multiple sclerosis and asthma. In multiple sclerosis Tim-2 and Tim-3 can influence the immune tolerance and inflammation rate affecting disease progression. These connections highlight Tim-2 as a potential target for therapeutic interventions in autoimmune and inflammatory diseases.
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