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AB276786

Recombinant Mouse TR-1 protein (Fc Chimera)

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Recombinant Mouse TR-1 protein (Fc Chimera) is a Mouse Fragment protein, in the 1 to 323 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Tomoregulin-1, TR-1, M7365, Transmembrane protein with EGF-like and one follistatin-like domain, Tmeff1

1 Images
SDS-PAGE - Recombinant Mouse TR-1 protein (Fc Chimera) (AB276786)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse TR-1 protein (Fc Chimera) (AB276786)

SDS-PAGE analysis of ab276786

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6PFE7

Animal free

No

Carrier free

No

Species

Mouse

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGAQAPLRLPAAPPLAVCGYTSVLLLFAFCLPGSRASNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGAEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV","proteinLength":"Fragment","predictedMolecularWeight":"57.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":323,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6PFE7","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TR-1 protein also known by the alternative name 'TR' is a thioredoxin reductase enzyme with a molecular mass of approximately 55 kDa. This protein is expressed in various tissues including the liver and heart and is part of the broader family of selenoproteins. TR-1 is responsible for catalyzing the reduction of thioredoxin using the electrons from NADPH to maintain a reducing environment in the cell. This activity is essential for various cellular processes ensuring the proper function and stability of cellular components.
Biological function summary

TR-1 plays an important role in the regulation of oxidative stress by maintaining the redox balance within the cell. It is an important component of a cellular complex involved in the detoxification of reactive oxygen species (ROS). Through its enzymatic activity TR-1 helps protect cells from oxidative damage and supports the regulation of cellular growth and apoptosis. Furthermore TR-1 influences DNA synthesis by facilitating ribonucleotide reductase activity highlighting its significance in cellular proliferation.

Pathways

TR-1 is involved in the antioxidant defense system and the regulation of apoptosis pathways. It interacts with proteins like thioredoxin and glutathione peroxidase in the ROS detoxification pathway highlighting its role in cellular defense mechanisms. Moreover the interaction of TR-1 with other redox-related proteins ensures the modulation of apoptotic signaling pathways therefore balancing cell survival and programmed cell death.

TR-1 shows a connection to cancer and neurodegenerative diseases. Altered TR-1 activity has been linked to cancer where it affects tumor growth due to its role in cell proliferation and survival. Dysregulated redox balance from TR-1 malfunction contributes to cancer cell resistance to therapy. Additionally in neurodegenerative diseases TR-1's involvement with proteins like glutathione peroxidase plays a part in mitigating cellular damage from oxidative stress thereby affecting the progression of neurodegenerative conditions.
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Specifications

Form

Lyophilized

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General info

Function

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed : 39048823). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity).

Sequence similarities

Belongs to the tomoregulin family.

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Product protocols

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Target data

Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed : 39048823). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity).
See full target information TR-1
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