Recombinant Mouse Tumor necrosis factor receptor superfamily member 26 protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tumor necrosis factor receptor superfamily member 26 often known as TNFRSF26 acts as a receptor for certain cytokines linking to specific signaling pathways. TNFRSF26 has a molecular mass of approximately 45 kDa. It is expressed in various tissues including immune system cells such as lymphocytes highlighting its role in immune regulation. This expression suggests its function is significant in facilitating cell communication and driving particular immune responses.

Biological function summary

TNFRSF26 contributes to immune system regulation and cellular apoptosis. It plays a role in complex assemblies that mediate interactions between different signaling molecules further influencing cell death and survival. Through its ligand-binding activities TNFRSF26 can activate specific signaling cascades that modulate inflammation and immune cell activation. This protein's function is critical in maintaining immune homeostasis and shaping the body’s response to various signals.

Pathways

TNFRSF26 plays a significant role in the TNF signaling pathway which controls diverse cellular responses including inflammation apoptosis and cell proliferation. The pathway involves several key proteins including TNF and TRAF (TNF receptor-associated factor) proteins which help transmit signals initiated by receptor-ligand binding. Another important pathway related to TNFRSF26 is the NF-kB pathway known for regulating immune response. This pathway supports adaptive and innate immune responses by mediating gene expression necessary for responding to external stressors effectively.

TNFRSF26 associates with conditions such as autoimmune diseases and certain types of cancer. Its dysregulation may result in abnormal immune responses leading to diseases like rheumatoid arthritis. TNFRSF26 interactions with the TNF cytokine contribute to inflammatory responses central to these disorders. In addition overeager or insufficient expression of TNFRSF26 can relate to cancer development due to its role in apoptosis and cell proliferation. Understanding its relationship with other proteins such as TNF and TRAF proteins is essential in developing targeted therapeutic interventions for these conditions.