Recombinant mouse Urokinase protein is a Mouse Full Length protein, in the 179 to 433 aa range, expressed in Insect, with >98% purity and suitable for SDS-PAGE, ELISA, FuncS.
K I V G G E F T E V E N Q P W F A A I Y Q K N K G G S P P S F K C G G S L I S P C W V A S A A H C F I Q L P K K E N Y V V Y L G Q S K E S S Y N P G E M K F E V E Q L I L H E Y Y R E D S L A Y H N D I A L L K I R T S T G Q C A Q P S R S I Q T I C L P P R F T D A P F G S D C E I T G F G K E S E S D Y L Y P K N L K M S V V K L V S H E Q C M Q P H Y Y G S E I N Y K M L C A A D P E W K T D S C K G D S G G P L I C N I E G R P T L S G I V S W G R G C A E K N K P G V Y T R V S H F L D W I Q S H I G E E K G L A F
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Urokinase-type plasminogen activator, U-plasminogen activator, uPA, Plau
Recombinant mouse Urokinase protein is a Mouse Full Length protein, in the 179 to 433 aa range, expressed in Insect, with >98% purity and suitable for SDS-PAGE, ELISA, FuncS.
pH: 5
Constituents: 0.58% Sodium chloride, 0.41% Sodium acetate, 0.0292% EDTA
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Belongs to the peptidase S1 family.
Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Spectrophotometric Data:
Ultraviolet Absorbance (280nm) = 0.9
epsilon 0.1% = 1.48
ab92641 demonstrates preferential binding to mouse uPAR over Human uPAR coated on an ELISA plate.
Produced using non-baculovirus insect cells.
Urokinase also known as urokinase-type plasminogen activator (uPA) is a serine protease with a molecular mass of approximately 54 kDa. It is expressed in various tissues including the kidneys liver and blood vessels. Urokinase initially forms as pro-urokinase an inactive precursor that can convert into the active enzyme. Researchers often use assays like the direct assay to measure urokinase activity due to its role in breaking down fibrin and modulating cell adhesion and migration.
Something particularly interesting about urokinase is its role in converting plasminogen to plasmin a critical enzyme in the process of fibrinolysis. Moreover it is part of a larger enzymatic complex involving the urokinase receptor (uPAR) which localizes plasminogen activation to cell surfaces. This complex mediates extracellular matrix degradation aiding in important cellular processes like tissue remodeling and wound healing.
Urokinase plays a critical role in the fibrinolytic pathway which involves the breakdown of blood clots. It also interacts with the extracellular matrix pathway by activating plasminogen which can degrade matrix components. In these pathways urokinase closely interacts with proteins such as plasmin and its inhibitor plasminogen activator inhibitor-1 (PAI-1) which regulate the activity and localization of proteolytic events.
Urokinase is strongly linked to conditions such as deep vein thrombosis and cancer metastasis. Its overexpression or dysregulation often leads to excessive tissue degradation influencing metastasis progression. Urokinase is connected to the urokinase receptor (uPAR) in cancer facilitating cancer cell invasion and migration. Understanding its behavior in these contexts is critical for developing therapeutic strategies and targeting treatments against these diseases.
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