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AB256445

Recombinant Nipah Virus Glycoprotein G

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Recombinant Nipah Virus Glycoprotein G is a Henipavirus nipahense Fragment protein, in the 71 to 602 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

View Alternative Names

Glycoprotein G, G

1 Images
SDS-PAGE - Recombinant Nipah Virus Glycoprotein G (AB256445)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Nipah Virus Glycoprotein G (AB256445)

SDS-PAGE analysis of 2 μg (Lane 1) and 0.2 μg (Lane 20 of ab256445 under reducing conditions.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9IH62

Animal free

No

Carrier free

No

Species

Henipavirus nipahense

Storage buffer

pH: 7 - 8 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"QNYTRSTDNQAVIKDALQGIQQQIKGLADKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTASINENVNEKCKFTLPPLKIHECNISCPNPLPFREYRPQTEGVSNLVGLPNNICLQKTSNQILKPKLISYTLPVVGQSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMPYGPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEICWEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDTGDNVIRPKLFAVKIPEQCT","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":602,"aminoAcidStart":71,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9IH62","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glycoprotein G often referred to simply as G is a surface protein found on the envelope of several viruses including the Nipah virus. It plays an essential mechanical role in viral entry into host cells. Specifically Glycoprotein G facilitates the attachment of the virus to host cell receptors initiating the fusion process. The protein is characterized by its significant molecular mass which varies depending on the specific virus subtype. Expression of Glycoprotein G is noted mainly in the viral envelope and is important for the infection process serving as a target for neutralizing antibodies.
Biological function summary

Glycoprotein G interacts with host cellular machinery to mediate virus-host cell fusion. This protein exists as part of a complex with the fusion protein F which together enable the virus to enter host cells. The complex's interaction with host cell receptors triggers conformational changes promoting membrane fusion and entry. This makes Glycoprotein G a critical component for the viral life cycle directly influencing infection efficiency and pathogenicity.

Pathways

Glycoprotein G plays an important role in the viral entry pathway. Its activity is closely intertwined with the fusion protein contributing to the successful fusion of viral and host cell membranes. The protein participates in viral life cycles that lead to the spread of the virus throughout the host organism. The effective functioning of Glycoprotein G within these pathways highlights its importance in viral propagation making it a target of interest in antiviral strategies.

Glycoprotein G has a significant relationship with viral infections such as those caused by the Nipah virus. These infections are associated with high morbidity and mortality making them a major public health concern. Glycoprotein G through its interaction with protein F influences the pathogenicity of the Nipah virus suggesting its role in the viral spread and severity of the disease. Understanding this protein's function and interactions with other viral components provides valuable insights for developing therapeutic interventions.
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Specifications

Form

Liquid

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General info

Function

Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.
See full target information Glycoprotein G
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Product promise

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